eIF2α links mitochondrial dysfunction to dendritic degeneration

Although mitochondrial dysfunction has been associated with dendritic pathology in many neuronal types, how mitochondrial impairment causes the vulnerability of neuronal subtypes remains unknown. In this issue, Tsuyama et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604065) identify eIF2α...

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Detalles Bibliográficos
Autor principal: Qi, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350525/
https://www.ncbi.nlm.nih.gov/pubmed/28209643
http://dx.doi.org/10.1083/jcb.201701062
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author Qi, Xin
author_facet Qi, Xin
author_sort Qi, Xin
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description Although mitochondrial dysfunction has been associated with dendritic pathology in many neuronal types, how mitochondrial impairment causes the vulnerability of neuronal subtypes remains unknown. In this issue, Tsuyama et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604065) identify eIF2α phosphorylation as a critical regulator of mitochondrial dysfunction-mediated selective dendritic loss in Drosophila neurons.
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spelling pubmed-53505252017-09-06 eIF2α links mitochondrial dysfunction to dendritic degeneration Qi, Xin J Cell Biol Commentary Although mitochondrial dysfunction has been associated with dendritic pathology in many neuronal types, how mitochondrial impairment causes the vulnerability of neuronal subtypes remains unknown. In this issue, Tsuyama et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201604065) identify eIF2α phosphorylation as a critical regulator of mitochondrial dysfunction-mediated selective dendritic loss in Drosophila neurons. The Rockefeller University Press 2017-03-06 /pmc/articles/PMC5350525/ /pubmed/28209643 http://dx.doi.org/10.1083/jcb.201701062 Text en © 2017 Qi http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Qi, Xin
eIF2α links mitochondrial dysfunction to dendritic degeneration
title eIF2α links mitochondrial dysfunction to dendritic degeneration
title_full eIF2α links mitochondrial dysfunction to dendritic degeneration
title_fullStr eIF2α links mitochondrial dysfunction to dendritic degeneration
title_full_unstemmed eIF2α links mitochondrial dysfunction to dendritic degeneration
title_short eIF2α links mitochondrial dysfunction to dendritic degeneration
title_sort eif2α links mitochondrial dysfunction to dendritic degeneration
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350525/
https://www.ncbi.nlm.nih.gov/pubmed/28209643
http://dx.doi.org/10.1083/jcb.201701062
work_keys_str_mv AT qixin eif2alinksmitochondrialdysfunctiontodendriticdegeneration

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