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The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males
Objective. This study aimed to identify the main determinants of serum leptin levels. Methods. A sample of 113 Saudi adult males (55 diabetic and 58 nondiabetic) was selected according to the inclusion and exclusion criteria identified below. Blood samples were taken from participants after fasting...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350535/ https://www.ncbi.nlm.nih.gov/pubmed/28348585 http://dx.doi.org/10.1155/2017/3506871 |
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author | Al Sheikh, Mona Hmoud |
author_facet | Al Sheikh, Mona Hmoud |
author_sort | Al Sheikh, Mona Hmoud |
collection | PubMed |
description | Objective. This study aimed to identify the main determinants of serum leptin levels. Methods. A sample of 113 Saudi adult males (55 diabetic and 58 nondiabetic) was selected according to the inclusion and exclusion criteria identified below. Blood samples were taken from participants after fasting for 12 hours. For diabetic patients, the insulin dose was given 12 hours before. In general, the study instrument consisted of blood biochemical tests. Metabolic parameters, glycosylated hemoglobin (HbA1c), low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, and triglyceride (TG), and adipokines, leptin, adiponectin, visfatin, and resistin, were measured. Multivariate model was utilized to identify the relationship between leptin levels and the independent variables. Results. When adjusted for resistin in the diabetic group, the results demonstrated a significant relationship between visfatin, LDL and TG, and leptin levels (p < 0.05). However, when controlled for resistin, the effect of LDL and TG disappeared while that of visfatin stayed in the model. For the nondiabetic group, the results indicated a significant relationship between insulin, BMI, and leptin levels when adjusted for resistin (p < 0.05). However, the effect of insulin disappeared when the model was controlled for resistin. The study results found no relationship between leptin and adiponectin levels in either the diabetic or nondiabetic group and whether adjusted or controlled for resistin. Conclusion. This study provided better understanding of the metabolism of leptin and unveiled the major determinants of leptin levels in diabetic and nondiabetic males. In conclusion, these results show that the association between leptin and metabolic parameters decreases with the progress of disease. |
format | Online Article Text |
id | pubmed-5350535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-53505352017-03-27 The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males Al Sheikh, Mona Hmoud Int J Endocrinol Research Article Objective. This study aimed to identify the main determinants of serum leptin levels. Methods. A sample of 113 Saudi adult males (55 diabetic and 58 nondiabetic) was selected according to the inclusion and exclusion criteria identified below. Blood samples were taken from participants after fasting for 12 hours. For diabetic patients, the insulin dose was given 12 hours before. In general, the study instrument consisted of blood biochemical tests. Metabolic parameters, glycosylated hemoglobin (HbA1c), low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, and triglyceride (TG), and adipokines, leptin, adiponectin, visfatin, and resistin, were measured. Multivariate model was utilized to identify the relationship between leptin levels and the independent variables. Results. When adjusted for resistin in the diabetic group, the results demonstrated a significant relationship between visfatin, LDL and TG, and leptin levels (p < 0.05). However, when controlled for resistin, the effect of LDL and TG disappeared while that of visfatin stayed in the model. For the nondiabetic group, the results indicated a significant relationship between insulin, BMI, and leptin levels when adjusted for resistin (p < 0.05). However, the effect of insulin disappeared when the model was controlled for resistin. The study results found no relationship between leptin and adiponectin levels in either the diabetic or nondiabetic group and whether adjusted or controlled for resistin. Conclusion. This study provided better understanding of the metabolism of leptin and unveiled the major determinants of leptin levels in diabetic and nondiabetic males. In conclusion, these results show that the association between leptin and metabolic parameters decreases with the progress of disease. Hindawi 2017 2017-03-01 /pmc/articles/PMC5350535/ /pubmed/28348585 http://dx.doi.org/10.1155/2017/3506871 Text en Copyright © 2017 Mona Hmoud Al Sheikh. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Al Sheikh, Mona Hmoud The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title | The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title_full | The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title_fullStr | The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title_full_unstemmed | The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title_short | The Determinants of Leptin Levels in Diabetic and Nondiabetic Saudi Males |
title_sort | determinants of leptin levels in diabetic and nondiabetic saudi males |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350535/ https://www.ncbi.nlm.nih.gov/pubmed/28348585 http://dx.doi.org/10.1155/2017/3506871 |
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