First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination

Enterobacteriaceae with bla(NDM-7) is only infrequently observed. Self-transmissible plasmids carrying the bla(NDM) gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a bla(NDM-7)-positive Escherichia coli. The isola...

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Autores principales: Devanga Ragupathi, N.K., Muthuirulandi Sethuvel, D.P., Gajendiran, R., Daniel, J.L.K., Walia, K., Veeraraghavan, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
New Resistant Microbes in Humans
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350569/
https://www.ncbi.nlm.nih.gov/pubmed/28337342
http://dx.doi.org/10.1016/j.nmni.2017.01.012
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author Devanga Ragupathi, N.K.
Muthuirulandi Sethuvel, D.P.
Gajendiran, R.
Daniel, J.L.K.
Walia, K.
Veeraraghavan, B.
author_facet Devanga Ragupathi, N.K.
Muthuirulandi Sethuvel, D.P.
Gajendiran, R.
Daniel, J.L.K.
Walia, K.
Veeraraghavan, B.
author_sort Devanga Ragupathi, N.K.
collection PubMed
description Enterobacteriaceae with bla(NDM-7) is only infrequently observed. Self-transmissible plasmids carrying the bla(NDM) gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a bla(NDM-7)-positive Escherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as E. coli ST-167 with IncX3 plasmid carrying bla(NDM-7) in addition to bla(TEM-1) and bla(CMY-42) genes. The identification of IncX3-bla(NDM-7) combination is the first report in India where bla(NDM-7) is known to cause higher resistance to carbapenems compared to its variants.
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spelling pubmed-53505692017-03-23 First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination Devanga Ragupathi, N.K. Muthuirulandi Sethuvel, D.P. Gajendiran, R. Daniel, J.L.K. Walia, K. Veeraraghavan, B. New Microbes New Infect New Resistant Microbes in Humans Enterobacteriaceae with bla(NDM-7) is only infrequently observed. Self-transmissible plasmids carrying the bla(NDM) gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a bla(NDM-7)-positive Escherichia coli. The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as E. coli ST-167 with IncX3 plasmid carrying bla(NDM-7) in addition to bla(TEM-1) and bla(CMY-42) genes. The identification of IncX3-bla(NDM-7) combination is the first report in India where bla(NDM-7) is known to cause higher resistance to carbapenems compared to its variants. Elsevier 2017-02-02 /pmc/articles/PMC5350569/ /pubmed/28337342 http://dx.doi.org/10.1016/j.nmni.2017.01.012 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle New Resistant Microbes in Humans
Devanga Ragupathi, N.K.
Muthuirulandi Sethuvel, D.P.
Gajendiran, R.
Daniel, J.L.K.
Walia, K.
Veeraraghavan, B.
First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title_full First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title_fullStr First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title_full_unstemmed First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title_short First Indian report of IncX3 plasmid carrying bla(NDM-7) in Escherichia coli from bloodstream infection: potential for rapid dissemination
title_sort first indian report of incx3 plasmid carrying bla(ndm-7) in escherichia coli from bloodstream infection: potential for rapid dissemination
topic New Resistant Microbes in Humans
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350569/
https://www.ncbi.nlm.nih.gov/pubmed/28337342
http://dx.doi.org/10.1016/j.nmni.2017.01.012
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