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Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway
Manipulation of the ubiquitin–proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer and other diseases. An increased understanding of the molecular mechanism of tha...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Portland Press Ltd.
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350610/ https://www.ncbi.nlm.nih.gov/pubmed/28298557 http://dx.doi.org/10.1042/BCJ20160762 |