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Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway

Manipulation of the ubiquitin–proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer and other diseases. An increased understanding of the molecular mechanism of tha...

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Detalles Bibliográficos
Autores principales:	Collins, Ian, Wang, Hannah, Caldwell, John J., Chopra, Raj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350610/ https://www.ncbi.nlm.nih.gov/pubmed/28298557 http://dx.doi.org/10.1042/BCJ20160762

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