Cargando…

Chemical approaches to targeted protein degradation through modulation of the ubiquitin–proteasome pathway

Manipulation of the ubiquitin–proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer and other diseases. An increased understanding of the molecular mechanism of tha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Collins, Ian, Wang, Hannah, Caldwell, John J., Chopra, Raj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2017
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5350610/ https://www.ncbi.nlm.nih.gov/pubmed/28298557 http://dx.doi.org/10.1042/BCJ20160762

Ejemplares similares

Targeting the MYC Ubiquitination-Proteasome Degradation Pathway for Cancer Therapy
por: Sun, Xiao-Xin, et al.
Publicado: (2021)

The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
por: Gu, Xin, et al.
Publicado: (2023)

Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
por: Ben-Nissan, Gili, et al.
Publicado: (2014)

Activin-β(C) modulates cachexia by repressing the ubiquitin-proteasome and autophagic degradation pathways
por: Marino, Francesco Elia, et al.
Publicado: (2015)

Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates
por: Korolchuk, Viktor I., et al.
Publicado: (2009)

Ubiquitin-independent proteasomal degradation driven by C-degron pathways
por: Makaros, Yaara, et al.
Publicado: (2023)

Rab21 Protein Is Degraded by Both the Ubiquitin-Proteasome Pathway and the Autophagy-Lysosome Pathway
por: Liu, Pinduo, et al.
Publicado: (2022)

Ubiquitin modulates 26S proteasome conformational dynamics and promotes substrate degradation
por: Jonsson, Erik, et al.
Publicado: (2022)

How the 26S Proteasome Degrades Ubiquitinated Proteins in the Cell
por: Coll-Martínez, Bernat, et al.
Publicado: (2019)

Ubiquitin-Proteasome System–Regulated Protein Degradation in Spermatogenesis
por: Xiong, Yi, et al.
Publicado: (2022)

Pharmacological Modulation of Ubiquitin-Proteasome Pathways in Oncogenic Signaling
por: Sharma, Anmol, et al.
Publicado: (2021)

Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation
por: Collins, Mahlon A, et al.
Publicado: (2022)

Avian Metapneumovirus Subgroup C Induces Mitochondrial Antiviral Signaling Protein Degradation through the Ubiquitin-Proteasome Pathway
por: Hou, Lei, et al.
Publicado: (2021)

Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
por: Sánchez-Lanzas, Raúl, et al.
Publicado: (2014)

The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy
por: Zientara-Rytter, Katarzyna, et al.
Publicado: (2019)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

Modulation of apoptosis sensitivity through the interplay with autophagic and proteasomal degradation pathways
por: Delgado, M E, et al.
Publicado: (2014)

Ribosomal proteins produced in excess are degraded by the ubiquitin–proteasome system
por: Sung, Min-Kyung, et al.
Publicado: (2016)

Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins
por: Abi Habib, Joanna, et al.
Publicado: (2020)

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway
por: Dimmeler, Stefanie, et al.
Publicado: (1999)

The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease
por: Nath, Samir R., et al.
Publicado: (2017)

Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation
por: Tsuchiya, Hikaru, et al.
Publicado: (2020)

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System
por: Abbas, Ruqaia, et al.
Publicado: (2021)

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation
por: Liu, Wei Jing, et al.
Publicado: (2016)

Limiting the power of p53 through the ubiquitin proteasome pathway
por: Pant, Vinod, et al.
Publicado: (2014)

TYROSINE PHOSPHORYLATION OF COFILIN AT Y68 BY V-SRC LEADS TO ITS DEGRADATION THROUGH UBIQUITIN-PROTEASOME PATHWAY
por: Yoo, Youngdong, et al.
Publicado: (2009)

A critical evaluation of the approaches to targeted protein degradation for drug discovery
por: Chopra, Rajesh, et al.
Publicado: (2019)

Targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients
por: Brun, Jan, et al.
Publicado: (2009)

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation
por: Lindsten, Kristina, et al.
Publicado: (2002)

Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively
por: Donnellan, Peter D, et al.
Publicado: (2009)

Immuno- and Constitutive Proteasomes Do Not Differ in Their Abilities to Degrade Ubiquitinated Proteins
por: Nathan, James A., et al.
Publicado: (2013)

Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation
por: Bialas, Johanna, et al.
Publicado: (2015)

The Ubiquitin-Proteasome Pathway in Huntington's Disease
por: Mitra, Siddhartha, et al.
Publicado: (2008)

Enzymatic Blockade of the Ubiquitin-Proteasome Pathway
por: Ernst, Robert, et al.
Publicado: (2011)

Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets
por: Bedford, Lynn, et al.
Publicado: (2010)

Camptothecin resistance is determined by the regulation of topoisomerase I degradation mediated by ubiquitin proteasome pathway
por: Ando, Koji, et al.
Publicado: (2017)

Ubiquitin Proteasome pathway proteins as potential drug targets in parasite Trypanosoma cruzi
por: Gupta, Ishita, et al.
Publicado: (2018)

Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast
por: Gatti, Laura, et al.
Publicado: (2011)

The tumor suppressor OVCA1 is a short half-life protein degraded by the ubiquitin-proteasome pathway
por: Lin, Yingwei, et al.
Publicado: (2019)

The role of the ubiquitination–proteasome pathway in breast cancer: Ubiquitin mediated degradation of growth factor receptors in the pathogenesis and treatment of cancer
por: Lipkowitz, Stan
Publicado: (2003)

Cannot write session to /tmp/vufind_sessions/sess_9mkn7t25innr7h2tr94ersfe54