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Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study

BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfun...

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Autores principales: Norvik, Jon V., Schirmer, Henrik, Ytrehus, Kirsti, Jenssen, Trond G., Zykova, Svetlana N., Eggen, Anne E., Eriksen, Bjørn O., Solbu, Marit D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351172/
https://www.ncbi.nlm.nih.gov/pubmed/28292262
http://dx.doi.org/10.1186/s12872-017-0509-2
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author Norvik, Jon V.
Schirmer, Henrik
Ytrehus, Kirsti
Jenssen, Trond G.
Zykova, Svetlana N.
Eggen, Anne E.
Eriksen, Bjørn O.
Solbu, Marit D.
author_facet Norvik, Jon V.
Schirmer, Henrik
Ytrehus, Kirsti
Jenssen, Trond G.
Zykova, Svetlana N.
Eggen, Anne E.
Eriksen, Bjørn O.
Solbu, Marit D.
author_sort Norvik, Jon V.
collection PubMed
description BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest. RESULTS: Decreased adiponectin was associated with higher odds of average tissue Doppler e’ < 9 in women (odds ratio [OR] 1.17 per 1 μg/mL adiponectin decrease, 95% confidence interval [CI] 1.04–1.30), but not in men (p for interaction with sex 0.04). Women, but not men, had higher odds of E/e’ ratio ≥ 8 with lower adiponectin (OR 1.12 per 1 μg/mL adiponectin decrease, 95% CI 1.02–1.24, p for interaction with sex 0.04). Adiponectin in the lower sex-specific tertile was associated with increased odds of concentric left ventricular hypertrophy in women (OR 2.44, 95% CI 1.03–5.77), but with decreased odds in men (OR 0.32, 95% CI 0.11–0.88, p for interaction with sex 0.002), and decreased odds of eccentric hypertrophy in men only (OR 0.53, 95% CI 0.33–0.88, p for interaction with sex 0.02). Adiponectin in the lower sex-specific tertile was associated with moderately enlarged left atria in women only (OR 1.43, 95% CI 1.01–2.03, p for interaction with sex 0.04). Finally, adiponectin had a non-linear relationship with left ventricular mass in women only, with exponentially increasing left ventricular mass with lower adiponectin levels (p for interaction with sex 0.01). CONCLUSIONS: Low adiponectin was associated with higher odds of indices of diastolic dysfunction in women, but lower odds of indices of diastolic dysfunction in men. Lower adiponectin was associated with increased left ventricular mass in women only.
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spelling pubmed-53511722017-03-17 Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study Norvik, Jon V. Schirmer, Henrik Ytrehus, Kirsti Jenssen, Trond G. Zykova, Svetlana N. Eggen, Anne E. Eriksen, Bjørn O. Solbu, Marit D. BMC Cardiovasc Disord Research Article BACKGROUND: Heart failure with preserved ejection fraction is closely associated with diastolic dysfunction and related to obesity and female sex. We investigated whether adiponectin, an adipocyte-secreted protein hormone with cardioprotective effects, was associated with indices of diastolic dysfunction, and whether the association was sex dependent. METHODS: We conducted a cross-sectional study on 1165 women and 896 men without diabetes. We stratified the multivariable adjusted logistic regression analyses and the fractional polynomial regression analyses according to sex, with echocardiographic markers of diastolic dysfunction as dependent variables, and adiponectin as the independent variable of interest. RESULTS: Decreased adiponectin was associated with higher odds of average tissue Doppler e’ < 9 in women (odds ratio [OR] 1.17 per 1 μg/mL adiponectin decrease, 95% confidence interval [CI] 1.04–1.30), but not in men (p for interaction with sex 0.04). Women, but not men, had higher odds of E/e’ ratio ≥ 8 with lower adiponectin (OR 1.12 per 1 μg/mL adiponectin decrease, 95% CI 1.02–1.24, p for interaction with sex 0.04). Adiponectin in the lower sex-specific tertile was associated with increased odds of concentric left ventricular hypertrophy in women (OR 2.44, 95% CI 1.03–5.77), but with decreased odds in men (OR 0.32, 95% CI 0.11–0.88, p for interaction with sex 0.002), and decreased odds of eccentric hypertrophy in men only (OR 0.53, 95% CI 0.33–0.88, p for interaction with sex 0.02). Adiponectin in the lower sex-specific tertile was associated with moderately enlarged left atria in women only (OR 1.43, 95% CI 1.01–2.03, p for interaction with sex 0.04). Finally, adiponectin had a non-linear relationship with left ventricular mass in women only, with exponentially increasing left ventricular mass with lower adiponectin levels (p for interaction with sex 0.01). CONCLUSIONS: Low adiponectin was associated with higher odds of indices of diastolic dysfunction in women, but lower odds of indices of diastolic dysfunction in men. Lower adiponectin was associated with increased left ventricular mass in women only. BioMed Central 2017-03-14 /pmc/articles/PMC5351172/ /pubmed/28292262 http://dx.doi.org/10.1186/s12872-017-0509-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Norvik, Jon V.
Schirmer, Henrik
Ytrehus, Kirsti
Jenssen, Trond G.
Zykova, Svetlana N.
Eggen, Anne E.
Eriksen, Bjørn O.
Solbu, Marit D.
Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title_full Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title_fullStr Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title_full_unstemmed Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title_short Low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the Tromsø Study
title_sort low adiponectin is associated with diastolic dysfunction in women: a cross-sectional study from the tromsø study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351172/
https://www.ncbi.nlm.nih.gov/pubmed/28292262
http://dx.doi.org/10.1186/s12872-017-0509-2
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