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Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism

The aim of the present study was to investigate the effect of resveratrol on renal carcinoma cells and explore possible renin-angiotensin system-associated mechanisms. Subsequent to resveratrol treatment, the cell viability, apoptosis rate, cytotoxicity levels, caspase 3/7 activity and the levels of...

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Autores principales: Li, Jianchang, Qiu, Mingning, Chen, Lieqian, Liu, Lei, Tan, Guobin, Liu, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351218/
https://www.ncbi.nlm.nih.gov/pubmed/28356937
http://dx.doi.org/10.3892/ol.2016.5519
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author Li, Jianchang
Qiu, Mingning
Chen, Lieqian
Liu, Lei
Tan, Guobin
Liu, Jianjun
author_facet Li, Jianchang
Qiu, Mingning
Chen, Lieqian
Liu, Lei
Tan, Guobin
Liu, Jianjun
author_sort Li, Jianchang
collection PubMed
description The aim of the present study was to investigate the effect of resveratrol on renal carcinoma cells and explore possible renin-angiotensin system-associated mechanisms. Subsequent to resveratrol treatment, the cell viability, apoptosis rate, cytotoxicity levels, caspase 3/7 activity and the levels of angiotensin II (AngII), AngII type 1 receptor (AT1R), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were evaluated in renal carcinoma cells. The effects of AngII, AT1R, VEGF and COX-2 on resveratrol-induced cell growth inhibition and apoptosis were also examined. The results indicated that resveratrol treatment may suppress growth, induce apoptosis, and decrease AngII, AT1R, VEGF and COX-2 levels in renal carcinoma ACHN and A498 cells. In addition, resveratrol-induced cell growth suppression and apoptosis were reversed when co-culturing with AT1R or VEGF. Thus, resveratrol may suppress renal carcinoma cell proliferation and induce apoptosis via an AT1R/VEGF pathway.
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spelling pubmed-53512182017-03-29 Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism Li, Jianchang Qiu, Mingning Chen, Lieqian Liu, Lei Tan, Guobin Liu, Jianjun Oncol Lett Articles The aim of the present study was to investigate the effect of resveratrol on renal carcinoma cells and explore possible renin-angiotensin system-associated mechanisms. Subsequent to resveratrol treatment, the cell viability, apoptosis rate, cytotoxicity levels, caspase 3/7 activity and the levels of angiotensin II (AngII), AngII type 1 receptor (AT1R), vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were evaluated in renal carcinoma cells. The effects of AngII, AT1R, VEGF and COX-2 on resveratrol-induced cell growth inhibition and apoptosis were also examined. The results indicated that resveratrol treatment may suppress growth, induce apoptosis, and decrease AngII, AT1R, VEGF and COX-2 levels in renal carcinoma ACHN and A498 cells. In addition, resveratrol-induced cell growth suppression and apoptosis were reversed when co-culturing with AT1R or VEGF. Thus, resveratrol may suppress renal carcinoma cell proliferation and induce apoptosis via an AT1R/VEGF pathway. D.A. Spandidos 2017-02 2016-12-20 /pmc/articles/PMC5351218/ /pubmed/28356937 http://dx.doi.org/10.3892/ol.2016.5519 Text en Copyright: © Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Li, Jianchang
Qiu, Mingning
Chen, Lieqian
Liu, Lei
Tan, Guobin
Liu, Jianjun
Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title_full Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title_fullStr Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title_full_unstemmed Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title_short Resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
title_sort resveratrol promotes regression of renal carcinoma cells via a renin-angiotensin system suppression-dependent mechanism
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351218/
https://www.ncbi.nlm.nih.gov/pubmed/28356937
http://dx.doi.org/10.3892/ol.2016.5519
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