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Immune mediators in the tumor microenvironment of prostate cancer
Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those re...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351274/ https://www.ncbi.nlm.nih.gov/pubmed/28292326 http://dx.doi.org/10.1186/s40880-017-0198-3 |
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author | Dai, Jinlu Lu, Yi Roca, Hernan Keller, Jill M. Zhang, Jian McCauley, Laurie K. Keller, Evan T. |
author_facet | Dai, Jinlu Lu, Yi Roca, Hernan Keller, Jill M. Zhang, Jian McCauley, Laurie K. Keller, Evan T. |
author_sort | Dai, Jinlu |
collection | PubMed |
description | Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can have both anti-tumor and pro-tumor activity. In addition, crosstalk between prostate cancer cells and immune cells affects immune cell functions. In this review, we focus on immune cells and cytokines that contribute to tumor progression. We discuss T-regulatory and T helper 17 cells and macrophages as key modulators in prostate cancer progression. In addition, we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy. |
format | Online Article Text |
id | pubmed-5351274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-53512742017-03-22 Immune mediators in the tumor microenvironment of prostate cancer Dai, Jinlu Lu, Yi Roca, Hernan Keller, Jill M. Zhang, Jian McCauley, Laurie K. Keller, Evan T. Chin J Cancer Review Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can have both anti-tumor and pro-tumor activity. In addition, crosstalk between prostate cancer cells and immune cells affects immune cell functions. In this review, we focus on immune cells and cytokines that contribute to tumor progression. We discuss T-regulatory and T helper 17 cells and macrophages as key modulators in prostate cancer progression. In addition, we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy. BioMed Central 2017-03-14 /pmc/articles/PMC5351274/ /pubmed/28292326 http://dx.doi.org/10.1186/s40880-017-0198-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Dai, Jinlu Lu, Yi Roca, Hernan Keller, Jill M. Zhang, Jian McCauley, Laurie K. Keller, Evan T. Immune mediators in the tumor microenvironment of prostate cancer |
title | Immune mediators in the tumor microenvironment of prostate cancer |
title_full | Immune mediators in the tumor microenvironment of prostate cancer |
title_fullStr | Immune mediators in the tumor microenvironment of prostate cancer |
title_full_unstemmed | Immune mediators in the tumor microenvironment of prostate cancer |
title_short | Immune mediators in the tumor microenvironment of prostate cancer |
title_sort | immune mediators in the tumor microenvironment of prostate cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351274/ https://www.ncbi.nlm.nih.gov/pubmed/28292326 http://dx.doi.org/10.1186/s40880-017-0198-3 |
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