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Immune mediators in the tumor microenvironment of prostate cancer

Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those re...

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Autores principales: Dai, Jinlu, Lu, Yi, Roca, Hernan, Keller, Jill M., Zhang, Jian, McCauley, Laurie K., Keller, Evan T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351274/
https://www.ncbi.nlm.nih.gov/pubmed/28292326
http://dx.doi.org/10.1186/s40880-017-0198-3
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author Dai, Jinlu
Lu, Yi
Roca, Hernan
Keller, Jill M.
Zhang, Jian
McCauley, Laurie K.
Keller, Evan T.
author_facet Dai, Jinlu
Lu, Yi
Roca, Hernan
Keller, Jill M.
Zhang, Jian
McCauley, Laurie K.
Keller, Evan T.
author_sort Dai, Jinlu
collection PubMed
description Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can have both anti-tumor and pro-tumor activity. In addition, crosstalk between prostate cancer cells and immune cells affects immune cell functions. In this review, we focus on immune cells and cytokines that contribute to tumor progression. We discuss T-regulatory and T helper 17 cells and macrophages as key modulators in prostate cancer progression. In addition, we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy.
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spelling pubmed-53512742017-03-22 Immune mediators in the tumor microenvironment of prostate cancer Dai, Jinlu Lu, Yi Roca, Hernan Keller, Jill M. Zhang, Jian McCauley, Laurie K. Keller, Evan T. Chin J Cancer Review Prostate cancer tissue is composed of both cancer cells and host cells. The milieu of host components that compose the tumor is termed the tumor microenvironment (TME). Host cells can be those derived from the tissue in which the tumor originates (e.g., fibroblasts and endothelial cells) or those recruited, through chemotactic or other factors, to the tumor (e.g., circulating immune cells). Some immune cells are key players in the TME and represent a large proportion of non-tumor cells found within the tumor. Immune cells can have both anti-tumor and pro-tumor activity. In addition, crosstalk between prostate cancer cells and immune cells affects immune cell functions. In this review, we focus on immune cells and cytokines that contribute to tumor progression. We discuss T-regulatory and T helper 17 cells and macrophages as key modulators in prostate cancer progression. In addition, we discuss the roles of interleukin-6 and receptor activator of nuclear factor kappa-B ligand in modulating prostate cancer progression. This review highlights the concept that immune cells and cytokines offer a potentially promising target for prostate cancer therapy. BioMed Central 2017-03-14 /pmc/articles/PMC5351274/ /pubmed/28292326 http://dx.doi.org/10.1186/s40880-017-0198-3 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Dai, Jinlu
Lu, Yi
Roca, Hernan
Keller, Jill M.
Zhang, Jian
McCauley, Laurie K.
Keller, Evan T.
Immune mediators in the tumor microenvironment of prostate cancer
title Immune mediators in the tumor microenvironment of prostate cancer
title_full Immune mediators in the tumor microenvironment of prostate cancer
title_fullStr Immune mediators in the tumor microenvironment of prostate cancer
title_full_unstemmed Immune mediators in the tumor microenvironment of prostate cancer
title_short Immune mediators in the tumor microenvironment of prostate cancer
title_sort immune mediators in the tumor microenvironment of prostate cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351274/
https://www.ncbi.nlm.nih.gov/pubmed/28292326
http://dx.doi.org/10.1186/s40880-017-0198-3
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