Pharmacokinetic and Pharmacodynamic Comparison of Sildenafil‐Bosentan and Sildenafil‐Ambrisentan Combination Therapies for Pulmonary Hypertension

To elucidate whether the pharmacokinetics (PK) and pharmacodynamics (PD) of sildenafil are influenced differently when it is coadministered with bosentan (S+B) or with ambrisentan (S+A), we evaluated the PK and PD profiles of sildenafil before and after 4–5 weeks of S+A or S+B treatment in patients...

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Detalles Bibliográficos
Autores principales: Hakamata, A, Odagiri, K, Miyakawa, S, Irisawa, H, Takeuchi, K, Inui, N, Tanaka, S, Uchida, S, Watanabe, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351320/
https://www.ncbi.nlm.nih.gov/pubmed/26756977
http://dx.doi.org/10.1111/cts.12382

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