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Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes

Vitamin A, via retinoic acid (RA), is a critical micronutrient. Normally, plasma concentrations are tightly regulated. Concentrations of vitamin A metabolites (13cis‐RA, atRA) and relationships between RBP4 and retinoids have never been fully evaluated in adult patients with CKD. We measured retinoi...

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Autores principales: Jing, J, Isoherranen, N, Robinson‐Cohen, C, Petrie, I, Kestenbaum, BR, Yeung, CK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351338/
https://www.ncbi.nlm.nih.gov/pubmed/27277845
http://dx.doi.org/10.1111/cts.12402
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author Jing, J
Isoherranen, N
Robinson‐Cohen, C
Petrie, I
Kestenbaum, BR
Yeung, CK
author_facet Jing, J
Isoherranen, N
Robinson‐Cohen, C
Petrie, I
Kestenbaum, BR
Yeung, CK
author_sort Jing, J
collection PubMed
description Vitamin A, via retinoic acid (RA), is a critical micronutrient. Normally, plasma concentrations are tightly regulated. Concentrations of vitamin A metabolites (13cis‐RA, atRA) and relationships between RBP4 and retinoids have never been fully evaluated in adult patients with CKD. We measured retinoid and RBP4 concentrations in plasma and urine from 55 adult patients with CKD and 21 matched healthy subjects. RBP4 and retinol levels were increased approximately twofold in patients with CKD, with a negative correlation between plasma retinol and eGFR (p = 0.006) and plasma RBP4 and eGFR (p = 0.0007). RBP4 renal clearance was higher in patients with CKD than healthy subjects but not associated with eGFR. Circulating concentrations of atRA increased and concentrations of 13cis‐RA decreased in subjects with CKD with no change in RA‐to‐retinol ratio. Increases in circulating retinol, RBP4, and atRA may be due to increased hepatic RBP4 synthesis, retinyl ester hydrolysis, and/or hepatic secretion of RBP4‐retinol.
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spelling pubmed-53513382017-05-23 Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes Jing, J Isoherranen, N Robinson‐Cohen, C Petrie, I Kestenbaum, BR Yeung, CK Clin Transl Sci Research Vitamin A, via retinoic acid (RA), is a critical micronutrient. Normally, plasma concentrations are tightly regulated. Concentrations of vitamin A metabolites (13cis‐RA, atRA) and relationships between RBP4 and retinoids have never been fully evaluated in adult patients with CKD. We measured retinoid and RBP4 concentrations in plasma and urine from 55 adult patients with CKD and 21 matched healthy subjects. RBP4 and retinol levels were increased approximately twofold in patients with CKD, with a negative correlation between plasma retinol and eGFR (p = 0.006) and plasma RBP4 and eGFR (p = 0.0007). RBP4 renal clearance was higher in patients with CKD than healthy subjects but not associated with eGFR. Circulating concentrations of atRA increased and concentrations of 13cis‐RA decreased in subjects with CKD with no change in RA‐to‐retinol ratio. Increases in circulating retinol, RBP4, and atRA may be due to increased hepatic RBP4 synthesis, retinyl ester hydrolysis, and/or hepatic secretion of RBP4‐retinol. John Wiley and Sons Inc. 2016-06-09 2016-08 /pmc/articles/PMC5351338/ /pubmed/27277845 http://dx.doi.org/10.1111/cts.12402 Text en © 2016 The Authors. Clinical and Translational Science published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research
Jing, J
Isoherranen, N
Robinson‐Cohen, C
Petrie, I
Kestenbaum, BR
Yeung, CK
Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title_full Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title_fullStr Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title_full_unstemmed Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title_short Chronic Kidney Disease Alters Vitamin A Homeostasis via Effects on Hepatic RBP4 Protein Expression and Metabolic Enzymes
title_sort chronic kidney disease alters vitamin a homeostasis via effects on hepatic rbp4 protein expression and metabolic enzymes
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351338/
https://www.ncbi.nlm.nih.gov/pubmed/27277845
http://dx.doi.org/10.1111/cts.12402
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