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Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model
The treatment of malignant tumors following surgery is important in preventing relapse. Among all the post-surgery treatments, immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies. Ginsenoside is a compound isolated from panax ginseng, which is...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351349/ https://www.ncbi.nlm.nih.gov/pubmed/28356946 http://dx.doi.org/10.3892/ol.2016.5490 |
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author | Wang, Meng Yan, Shi-Ju Zhang, Hong-Tao Li, Nan Liu, Tao Zhang, Ying-Long Li, Xiao-Xiang Ma, Qiong Qiu, Xiu-Chun Fan, Qing-Yu Ma, Bao-An |
author_facet | Wang, Meng Yan, Shi-Ju Zhang, Hong-Tao Li, Nan Liu, Tao Zhang, Ying-Long Li, Xiao-Xiang Ma, Qiong Qiu, Xiu-Chun Fan, Qing-Yu Ma, Bao-An |
author_sort | Wang, Meng |
collection | PubMed |
description | The treatment of malignant tumors following surgery is important in preventing relapse. Among all the post-surgery treatments, immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies. Ginsenoside is a compound isolated from panax ginseng, which is a famous traditional Chinese medicine. Ginsenoside aids in killing tumor cells through numerous processes, including the antitumor processes of ginsenoside Rh2 and Rg1, and also affects the inflammatory processes of the immune system. However, the role that ginsenoside serves in antitumor immunological activity remains to be elucidated. Therefore, the present study aimed to analyze the effect of ginsenoside Rh2 on the antitumor immunological response. With a melanoma mice model, ginsenoside Rh2 was demonstrated to inhibit tumor growth and improved the survival time of the mice. Ginsenoside Rh2 enhanced T-lymphocyte infiltration in the tumor and triggered cytotoxicity in spleen lymphocytes. In addition, the immunological response triggered by ginsenoside Rh2 could be transferred to other mice. In conclusion, the present study provides evidence that ginsenoside Rh2 treatment enhanced the antitumor immunological response, which may be a potential therapy for melanoma. |
format | Online Article Text |
id | pubmed-5351349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-53513492017-03-29 Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model Wang, Meng Yan, Shi-Ju Zhang, Hong-Tao Li, Nan Liu, Tao Zhang, Ying-Long Li, Xiao-Xiang Ma, Qiong Qiu, Xiu-Chun Fan, Qing-Yu Ma, Bao-An Oncol Lett Articles The treatment of malignant tumors following surgery is important in preventing relapse. Among all the post-surgery treatments, immunomodulators have demonstrated satisfactory effects on preventing recurrence according to recent studies. Ginsenoside is a compound isolated from panax ginseng, which is a famous traditional Chinese medicine. Ginsenoside aids in killing tumor cells through numerous processes, including the antitumor processes of ginsenoside Rh2 and Rg1, and also affects the inflammatory processes of the immune system. However, the role that ginsenoside serves in antitumor immunological activity remains to be elucidated. Therefore, the present study aimed to analyze the effect of ginsenoside Rh2 on the antitumor immunological response. With a melanoma mice model, ginsenoside Rh2 was demonstrated to inhibit tumor growth and improved the survival time of the mice. Ginsenoside Rh2 enhanced T-lymphocyte infiltration in the tumor and triggered cytotoxicity in spleen lymphocytes. In addition, the immunological response triggered by ginsenoside Rh2 could be transferred to other mice. In conclusion, the present study provides evidence that ginsenoside Rh2 treatment enhanced the antitumor immunological response, which may be a potential therapy for melanoma. D.A. Spandidos 2017-02 2016-12-12 /pmc/articles/PMC5351349/ /pubmed/28356946 http://dx.doi.org/10.3892/ol.2016.5490 Text en Copyright: © Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Wang, Meng Yan, Shi-Ju Zhang, Hong-Tao Li, Nan Liu, Tao Zhang, Ying-Long Li, Xiao-Xiang Ma, Qiong Qiu, Xiu-Chun Fan, Qing-Yu Ma, Bao-An Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title | Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title_full | Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title_fullStr | Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title_full_unstemmed | Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title_short | Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice model |
title_sort | ginsenoside rh2 enhances the antitumor immunological response of a melanoma mice model |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351349/ https://www.ncbi.nlm.nih.gov/pubmed/28356946 http://dx.doi.org/10.3892/ol.2016.5490 |
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