CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice

Despite the existence of various databases cataloging cancer drugs, there is an emerging need to support the development and application of personalized therapies, where an integrated understanding of the clinical factors and drug mechanism of action and its gene targets is necessary. We have develo...

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Autores principales: Soysal, E, Lee, H‐J, Zhang, Y, Huang, L‐C, Chen, X, Wei, Q, Zheng, W, Chang, JT, Cohen, T, Sun, J, Xu, H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351410/
https://www.ncbi.nlm.nih.gov/pubmed/28296354
http://dx.doi.org/10.1002/psp4.12174
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author Soysal, E
Lee, H‐J
Zhang, Y
Huang, L‐C
Chen, X
Wei, Q
Zheng, W
Chang, JT
Cohen, T
Sun, J
Xu, H
author_facet Soysal, E
Lee, H‐J
Zhang, Y
Huang, L‐C
Chen, X
Wei, Q
Zheng, W
Chang, JT
Cohen, T
Sun, J
Xu, H
author_sort Soysal, E
collection PubMed
description Despite the existence of various databases cataloging cancer drugs, there is an emerging need to support the development and application of personalized therapies, where an integrated understanding of the clinical factors and drug mechanism of action and its gene targets is necessary. We have developed CATTLE (CAncer Treatment Treasury with Linked Evidence), a comprehensive cancer drug knowledge base providing information across the complete spectrum of the drug life cycle. The CATTLE system collects relevant data from 22 heterogeneous databases, integrates them into a unified model centralized on drugs, and presents comprehensive drug information via an interactive web portal with a download function. A total of 2,323 unique cancer drugs are currently linked to rich information from these databases in CATTLE. Through two use cases, we demonstrate that CATTLE can be used in supporting both research and practice in personalized oncology.
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spelling pubmed-53514102017-03-22 CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice Soysal, E Lee, H‐J Zhang, Y Huang, L‐C Chen, X Wei, Q Zheng, W Chang, JT Cohen, T Sun, J Xu, H CPT Pharmacometrics Syst Pharmacol Original Articles Despite the existence of various databases cataloging cancer drugs, there is an emerging need to support the development and application of personalized therapies, where an integrated understanding of the clinical factors and drug mechanism of action and its gene targets is necessary. We have developed CATTLE (CAncer Treatment Treasury with Linked Evidence), a comprehensive cancer drug knowledge base providing information across the complete spectrum of the drug life cycle. The CATTLE system collects relevant data from 22 heterogeneous databases, integrates them into a unified model centralized on drugs, and presents comprehensive drug information via an interactive web portal with a download function. A total of 2,323 unique cancer drugs are currently linked to rich information from these databases in CATTLE. Through two use cases, we demonstrate that CATTLE can be used in supporting both research and practice in personalized oncology. John Wiley and Sons Inc. 2017-03-13 2017-03 /pmc/articles/PMC5351410/ /pubmed/28296354 http://dx.doi.org/10.1002/psp4.12174 Text en © 2017 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Soysal, E
Lee, H‐J
Zhang, Y
Huang, L‐C
Chen, X
Wei, Q
Zheng, W
Chang, JT
Cohen, T
Sun, J
Xu, H
CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title_full CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title_fullStr CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title_full_unstemmed CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title_short CATTLE (CAncer treatment treasury with linked evidence): An integrated knowledge base for personalized oncology research and practice
title_sort cattle (cancer treatment treasury with linked evidence): an integrated knowledge base for personalized oncology research and practice
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351410/
https://www.ncbi.nlm.nih.gov/pubmed/28296354
http://dx.doi.org/10.1002/psp4.12174
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