Identification of Filamin-A and -B as potential biomarkers for prostate cancer

AIM: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. MATERIALS & METHODS: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. RESULTS: Filamin-B (FLNB) and Kerati...

Descripción completa

Detalles Bibliográficos
Autores principales: Narain, Niven R, Diers, Anne R, Lee, Arleide, Lao, Socheata, Chan, Joyce Y, Schofield, Sally, Andreazi, Joe, Ouro-Djobo, Rakibou, Jimenez, Joaquin J, Friss, Tracey, Tanna, Nikunj, Dalvi, Aditee, Wang, Sihe, Bunch, Dustin, Sun, Yezhou, Wu, Wenfang, Thapa, Khampaseuth, Gesta, Stephane, Rodrigues, Leonardo O, Akmaev, Viatcheslav R, Vishnudas, Vivek K, Sarangarajan, Rangaprasad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351499/
https://www.ncbi.nlm.nih.gov/pubmed/28344825
http://dx.doi.org/10.4155/fsoa-2016-0065
Descripción
Sumario:AIM: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. MATERIALS & METHODS: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. RESULTS: Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in patients with adenocarcinoma the relationship is dysregulated. CONCLUSION: These data support the strategy and the potential use of the biomarkers for PrCa.

Ejemplares similares