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Identification of Filamin-A and -B as potential biomarkers for prostate cancer
AIM: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. MATERIALS & METHODS: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. RESULTS: Filamin-B (FLNB) and Kerati...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Future Science Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351499/ https://www.ncbi.nlm.nih.gov/pubmed/28344825 http://dx.doi.org/10.4155/fsoa-2016-0065 |
| _version_ | 1782514775079518208 |
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| author | Narain, Niven R Diers, Anne R Lee, Arleide Lao, Socheata Chan, Joyce Y Schofield, Sally Andreazi, Joe Ouro-Djobo, Rakibou Jimenez, Joaquin J Friss, Tracey Tanna, Nikunj Dalvi, Aditee Wang, Sihe Bunch, Dustin Sun, Yezhou Wu, Wenfang Thapa, Khampaseuth Gesta, Stephane Rodrigues, Leonardo O Akmaev, Viatcheslav R Vishnudas, Vivek K Sarangarajan, Rangaprasad |
| author_facet | Narain, Niven R Diers, Anne R Lee, Arleide Lao, Socheata Chan, Joyce Y Schofield, Sally Andreazi, Joe Ouro-Djobo, Rakibou Jimenez, Joaquin J Friss, Tracey Tanna, Nikunj Dalvi, Aditee Wang, Sihe Bunch, Dustin Sun, Yezhou Wu, Wenfang Thapa, Khampaseuth Gesta, Stephane Rodrigues, Leonardo O Akmaev, Viatcheslav R Vishnudas, Vivek K Sarangarajan, Rangaprasad |
| author_sort | Narain, Niven R |
| collection | PubMed |
| description | AIM: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. MATERIALS & METHODS: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. RESULTS: Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in patients with adenocarcinoma the relationship is dysregulated. CONCLUSION: These data support the strategy and the potential use of the biomarkers for PrCa. |
| format | Online Article Text |
| id | pubmed-5351499 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2016 |
| publisher | Future Science Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-53514992017-03-24 Identification of Filamin-A and -B as potential biomarkers for prostate cancer Narain, Niven R Diers, Anne R Lee, Arleide Lao, Socheata Chan, Joyce Y Schofield, Sally Andreazi, Joe Ouro-Djobo, Rakibou Jimenez, Joaquin J Friss, Tracey Tanna, Nikunj Dalvi, Aditee Wang, Sihe Bunch, Dustin Sun, Yezhou Wu, Wenfang Thapa, Khampaseuth Gesta, Stephane Rodrigues, Leonardo O Akmaev, Viatcheslav R Vishnudas, Vivek K Sarangarajan, Rangaprasad Future Sci OA Research Article AIM: A novel strategy for prostate cancer (PrCa) biomarker discovery is described. MATERIALS & METHODS: In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens. RESULTS: Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in patients with adenocarcinoma the relationship is dysregulated. CONCLUSION: These data support the strategy and the potential use of the biomarkers for PrCa. Future Science Ltd 2016-12-22 /pmc/articles/PMC5351499/ /pubmed/28344825 http://dx.doi.org/10.4155/fsoa-2016-0065 Text en © BERG, LLC This work is licensed under a Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/) |
| spellingShingle | Research Article Narain, Niven R Diers, Anne R Lee, Arleide Lao, Socheata Chan, Joyce Y Schofield, Sally Andreazi, Joe Ouro-Djobo, Rakibou Jimenez, Joaquin J Friss, Tracey Tanna, Nikunj Dalvi, Aditee Wang, Sihe Bunch, Dustin Sun, Yezhou Wu, Wenfang Thapa, Khampaseuth Gesta, Stephane Rodrigues, Leonardo O Akmaev, Viatcheslav R Vishnudas, Vivek K Sarangarajan, Rangaprasad Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title | Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title_full | Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title_fullStr | Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title_full_unstemmed | Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title_short | Identification of Filamin-A and -B as potential biomarkers for prostate cancer |
| title_sort | identification of filamin-a and -b as potential biomarkers for prostate cancer |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351499/ https://www.ncbi.nlm.nih.gov/pubmed/28344825 http://dx.doi.org/10.4155/fsoa-2016-0065 |
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