Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors

Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that...

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Detalles Bibliográficos
Autores principales: Kroemer, Guido, Galluzzi, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351581/
https://www.ncbi.nlm.nih.gov/pubmed/27974686
http://dx.doi.org/10.18632/oncotarget.13892
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author Kroemer, Guido
Galluzzi, Lorenzo
author_facet Kroemer, Guido
Galluzzi, Lorenzo
author_sort Kroemer, Guido
collection PubMed
description Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling.
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spelling pubmed-53515812017-04-13 Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors Kroemer, Guido Galluzzi, Lorenzo Oncotarget Research Perspective Recent data suggest that autophagy does not influence spontaneous and therapy-elicited tumor infiltration by immune cells in murine models of melanoma and breast carcinoma. These findings, which have been obtained in the absence of a therapeutically relevant anticancer immune response, indicate that the intrinsically low immunogenicity of some tumors cannot be compensated for by increased danger signaling. Impact Journals LLC 2016-12-10 /pmc/articles/PMC5351581/ /pubmed/27974686 http://dx.doi.org/10.18632/oncotarget.13892 Text en Copyright: © 2017 Kroemer and Galluzzi http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Perspective
Kroemer, Guido
Galluzzi, Lorenzo
Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title_full Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title_fullStr Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title_full_unstemmed Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title_short Autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
title_sort autophagy-dependent danger signaling and adaptive immunity to poorly immunogenic tumors
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351581/
https://www.ncbi.nlm.nih.gov/pubmed/27974686
http://dx.doi.org/10.18632/oncotarget.13892
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AT galluzzilorenzo autophagydependentdangersignalingandadaptiveimmunitytopoorlyimmunogenictumors

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