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Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351591/ https://www.ncbi.nlm.nih.gov/pubmed/28008143 http://dx.doi.org/10.18632/oncotarget.14023 |
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author | Li, Yan Lu, De-guo Ma, Ying-mei Liu, Hongxiang |
author_facet | Li, Yan Lu, De-guo Ma, Ying-mei Liu, Hongxiang |
author_sort | Li, Yan |
collection | PubMed |
description | Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a meta-analysis to determine the effects of RARβ hypermethylation on the incidence of NSCLC and clinicopathological characteristics in human NSCLC patients. Final valuation and analysis of 1780 cancer patients from 16 eligible studies was performed. RARβ hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue, the pooled OR from 7 studies including 646 NSCLC and 580 normal lung tissues, OR = 6.05, 95% CI = 3.56-10.25, p<0.00001. RARβ hypermethylation was significantly higher in adenocarcinoma (AC) compared to squamous cell carcinoma (SCC), pooled OR is 0.68 (95% CI = 0.52-0.89, p = 0.005). RARβ hypermethylation was also found to occur significantly higher in smoker (n = 232) than non-smoker (n = 213) (OR = 2.46, 95% CI = 1.54-3.93, p = 0.0002). Our results indicate that RARβ hypermethylation correlates well with an increased risk in NSCLC patients. RARβ geneinactivation caused by RARβ methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. |
format | Online Article Text |
id | pubmed-5351591 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53515912017-04-13 Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review Li, Yan Lu, De-guo Ma, Ying-mei Liu, Hongxiang Oncotarget Research Paper Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a meta-analysis to determine the effects of RARβ hypermethylation on the incidence of NSCLC and clinicopathological characteristics in human NSCLC patients. Final valuation and analysis of 1780 cancer patients from 16 eligible studies was performed. RARβ hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue, the pooled OR from 7 studies including 646 NSCLC and 580 normal lung tissues, OR = 6.05, 95% CI = 3.56-10.25, p<0.00001. RARβ hypermethylation was significantly higher in adenocarcinoma (AC) compared to squamous cell carcinoma (SCC), pooled OR is 0.68 (95% CI = 0.52-0.89, p = 0.005). RARβ hypermethylation was also found to occur significantly higher in smoker (n = 232) than non-smoker (n = 213) (OR = 2.46, 95% CI = 1.54-3.93, p = 0.0002). Our results indicate that RARβ hypermethylation correlates well with an increased risk in NSCLC patients. RARβ geneinactivation caused by RARβ methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. Impact Journals LLC 2016-12-19 /pmc/articles/PMC5351591/ /pubmed/28008143 http://dx.doi.org/10.18632/oncotarget.14023 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Li, Yan Lu, De-guo Ma, Ying-mei Liu, Hongxiang Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title | Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title_full | Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title_fullStr | Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title_full_unstemmed | Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title_short | Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review |
title_sort | association between retinoic acid receptor-β hypermethylation and nsclc risk: a meta-analysis and literature review |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351591/ https://www.ncbi.nlm.nih.gov/pubmed/28008143 http://dx.doi.org/10.18632/oncotarget.14023 |
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