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Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review

Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a...

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Autores principales: Li, Yan, Lu, De-guo, Ma, Ying-mei, Liu, Hongxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351591/
https://www.ncbi.nlm.nih.gov/pubmed/28008143
http://dx.doi.org/10.18632/oncotarget.14023
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author Li, Yan
Lu, De-guo
Ma, Ying-mei
Liu, Hongxiang
author_facet Li, Yan
Lu, De-guo
Ma, Ying-mei
Liu, Hongxiang
author_sort Li, Yan
collection PubMed
description Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a meta-analysis to determine the effects of RARβ hypermethylation on the incidence of NSCLC and clinicopathological characteristics in human NSCLC patients. Final valuation and analysis of 1780 cancer patients from 16 eligible studies was performed. RARβ hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue, the pooled OR from 7 studies including 646 NSCLC and 580 normal lung tissues, OR = 6.05, 95% CI = 3.56-10.25, p<0.00001. RARβ hypermethylation was significantly higher in adenocarcinoma (AC) compared to squamous cell carcinoma (SCC), pooled OR is 0.68 (95% CI = 0.52-0.89, p = 0.005). RARβ hypermethylation was also found to occur significantly higher in smoker (n = 232) than non-smoker (n = 213) (OR = 2.46, 95% CI = 1.54-3.93, p = 0.0002). Our results indicate that RARβ hypermethylation correlates well with an increased risk in NSCLC patients. RARβ geneinactivation caused by RARβ methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC.
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spelling pubmed-53515912017-04-13 Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review Li, Yan Lu, De-guo Ma, Ying-mei Liu, Hongxiang Oncotarget Research Paper Emerging evidence indicates that Retinoic acid receptor-β (RARβ) is a tumor suppressor in many types of tumor. However, whether or not RARβ is a risk factor and is correlated to clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains unclear. In this report, we performed a meta-analysis to determine the effects of RARβ hypermethylation on the incidence of NSCLC and clinicopathological characteristics in human NSCLC patients. Final valuation and analysis of 1780 cancer patients from 16 eligible studies was performed. RARβ hypermethylation was found to be significantly higher in NSCLC than in normal lung tissue, the pooled OR from 7 studies including 646 NSCLC and 580 normal lung tissues, OR = 6.05, 95% CI = 3.56-10.25, p<0.00001. RARβ hypermethylation was significantly higher in adenocarcinoma (AC) compared to squamous cell carcinoma (SCC), pooled OR is 0.68 (95% CI = 0.52-0.89, p = 0.005). RARβ hypermethylation was also found to occur significantly higher in smoker (n = 232) than non-smoker (n = 213) (OR = 2.46, 95% CI = 1.54-3.93, p = 0.0002). Our results indicate that RARβ hypermethylation correlates well with an increased risk in NSCLC patients. RARβ geneinactivation caused by RARβ methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. Impact Journals LLC 2016-12-19 /pmc/articles/PMC5351591/ /pubmed/28008143 http://dx.doi.org/10.18632/oncotarget.14023 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Li, Yan
Lu, De-guo
Ma, Ying-mei
Liu, Hongxiang
Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title_full Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title_fullStr Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title_full_unstemmed Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title_short Association between Retinoic acid receptor-β hypermethylation and NSCLC risk: a meta-analysis and literature review
title_sort association between retinoic acid receptor-β hypermethylation and nsclc risk: a meta-analysis and literature review
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351591/
https://www.ncbi.nlm.nih.gov/pubmed/28008143
http://dx.doi.org/10.18632/oncotarget.14023
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