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Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis

BACKGROUND: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the pro...

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Autores principales: Lu, Jiaqi, Tao, Xiang, Zhou, Jiayi, Lu, Yingying, Wang, Zehua, Liu, Haiou, Xu, Congjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351594/
https://www.ncbi.nlm.nih.gov/pubmed/27992377
http://dx.doi.org/10.18632/oncotarget.13967
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author Lu, Jiaqi
Tao, Xiang
Zhou, Jiayi
Lu, Yingying
Wang, Zehua
Liu, Haiou
Xu, Congjian
author_facet Lu, Jiaqi
Tao, Xiang
Zhou, Jiayi
Lu, Yingying
Wang, Zehua
Liu, Haiou
Xu, Congjian
author_sort Lu, Jiaqi
collection PubMed
description BACKGROUND: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the prognosis in patients with ovarian cancer. RESULTS: Ovarian cancer arising in endometriosis tended to be presented as clear cell histology, early stage, less intraperitoneal metastasis and ascites, and lower CA125 level compared with those without endometriosis. Multivariate Cox regression analysis identified endometriosis as an independent prognostic factor for progression free survival (P = 0.002) and overall survival (P = 0.009) in all patients and especially for early stage. A nomogram integrating endometriosis, FIGO stage and CA125 was established to predict progression free survival and overall survival. MATERIALS AND METHODS: This study retrospectively enrolled 196 ovarian cancers arising or not in endometriosis judged by adjunctive use of CD10 immunohistochemistry in conjunction with H&E staining specimens. Clinicopathologic variables, progression-free survival (PFS) and overall survival (OS) were recorded. Kaplan-Meier analysis was performed to compare survival curves. Cox regression models were used to analyze the effect of endometriosis on PFS and OS. A prognostic nomogram was constructed based on the independent prognostic factors identified by multivariate analysis. CONCLUSIONS: Endometriosis is an independent predictor of prognosis in ovarian cancer patients.
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spelling pubmed-53515942017-04-13 Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis Lu, Jiaqi Tao, Xiang Zhou, Jiayi Lu, Yingying Wang, Zehua Liu, Haiou Xu, Congjian Oncotarget Research Paper BACKGROUND: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the prognosis in patients with ovarian cancer. RESULTS: Ovarian cancer arising in endometriosis tended to be presented as clear cell histology, early stage, less intraperitoneal metastasis and ascites, and lower CA125 level compared with those without endometriosis. Multivariate Cox regression analysis identified endometriosis as an independent prognostic factor for progression free survival (P = 0.002) and overall survival (P = 0.009) in all patients and especially for early stage. A nomogram integrating endometriosis, FIGO stage and CA125 was established to predict progression free survival and overall survival. MATERIALS AND METHODS: This study retrospectively enrolled 196 ovarian cancers arising or not in endometriosis judged by adjunctive use of CD10 immunohistochemistry in conjunction with H&E staining specimens. Clinicopathologic variables, progression-free survival (PFS) and overall survival (OS) were recorded. Kaplan-Meier analysis was performed to compare survival curves. Cox regression models were used to analyze the effect of endometriosis on PFS and OS. A prognostic nomogram was constructed based on the independent prognostic factors identified by multivariate analysis. CONCLUSIONS: Endometriosis is an independent predictor of prognosis in ovarian cancer patients. Impact Journals LLC 2016-12-15 /pmc/articles/PMC5351594/ /pubmed/27992377 http://dx.doi.org/10.18632/oncotarget.13967 Text en Copyright: © 2017 Lu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Lu, Jiaqi
Tao, Xiang
Zhou, Jiayi
Lu, Yingying
Wang, Zehua
Liu, Haiou
Xu, Congjian
Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title_full Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title_fullStr Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title_full_unstemmed Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title_short Improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
title_sort improved clinical outcomes of patients with ovarian carcinoma arising in endometriosis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351594/
https://www.ncbi.nlm.nih.gov/pubmed/27992377
http://dx.doi.org/10.18632/oncotarget.13967
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