In vitro and in vivo anti-leukemic activity of the peptidase-potentiated alkylator melflufen in acute myeloid leukemia

The novel aminopeptidase potentiated alkylating agent melflufen, was evaluated for activity in acute myeloid leukemia in a range of in vitro models, as well as in a patient derived xenograft study. All tested AML cell lines were highly sensitive to melflufen while melphalan was considerably less pot...

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Detalles Bibliográficos
Autores principales: Strese, Sara, Bashir Saadia, Hassan, Velander, Ebba, Haglund, Caroline, Höglund, Martin, Larsson, Rolf, Gullbo, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351636/
https://www.ncbi.nlm.nih.gov/pubmed/27974676
http://dx.doi.org/10.18632/oncotarget.13856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351636/
https://www.ncbi.nlm.nih.gov/pubmed/27974676
http://dx.doi.org/10.18632/oncotarget.13856

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