Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient reducing potential. Here we report that PKM2 is succinylated at lysine...

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Detalles Bibliográficos
Autores principales: Xiangyun, Ye, Xiaomin, Niu, linping, Gu, Yunhua, Xu, Ziming, Li, Yongfeng, Yu, Zhiwei, Chen, Shun, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351684/
https://www.ncbi.nlm.nih.gov/pubmed/28036303
http://dx.doi.org/10.18632/oncotarget.14346

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351684/
https://www.ncbi.nlm.nih.gov/pubmed/28036303
http://dx.doi.org/10.18632/oncotarget.14346

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