Cargando…

Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth

Tumor cells trends to express high level of pyruvate kinase M2 (PKM2). The inhibition of PKM2 activity is needed for antioxidant response by diverting glucose flux into the pentose phosphate pathway and thus generating sufficient reducing potential. Here we report that PKM2 is succinylated at lysine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiangyun, Ye, Xiaomin, Niu, linping, Gu, Yunhua, Xu, Ziming, Li, Yongfeng, Yu, Zhiwei, Chen, Shun, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351684/ https://www.ncbi.nlm.nih.gov/pubmed/28036303 http://dx.doi.org/10.18632/oncotarget.14346

Ejemplares similares

Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase
por: Zhu, Yuanfeng, et al.
Publicado: (2022)

Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy
por: Zhang, Ye, et al.
Publicado: (2022)

SMO mutation predicts the effect of immune checkpoint inhibitor: From NSCLC to multiple cancers
por: Ji, Wenxiang, et al.
Publicado: (2022)

The predictive role of pretreatment epidermal growth factor receptor T790M mutation on the progression-free survival of tyrosine-kinase inhibitor-treated non-small cell lung cancer patients: a meta-analysis
por: Ding, Ding, et al.
Publicado: (2014)

SIRT5-related desuccinylation modification of AIFM1 protects against compression-induced intervertebral disc degeneration by regulating mitochondrial homeostasis
por: Mao, Jianxin, et al.
Publicado: (2023)

Landscape and Predictive Significance of the Structural Classification of EGFR Mutations in Chinese NSCLCs: A Real-World Study
por: Gu, Linping, et al.
Publicado: (2022)

SIRT5-Related Desuccinylation Modification Contributes to Quercetin-Induced Protection against Heart Failure and High-Glucose-Prompted Cardiomyocytes Injured through Regulation of Mitochondrial Quality Surveillance
por: Chang, Xing, et al.
Publicado: (2021)

Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review
por: Chen, Zhiwei, et al.
Publicado: (2013)

HDAC1/2/3 are major histone desuccinylases critical for promoter desuccinylation
por: Li, Jialun, et al.
Publicado: (2023)

Deacetylation and Desuccinylation of the Fucose-Rich Polysaccharide Fucopol: Impact on Biopolymer Physical and Chemical Properties
por: Baptista, Sílvia, et al.
Publicado: (2022)

Pyruvate Kinase M2 Mediates Glycolysis Contributes to Psoriasis by Promoting Keratinocyte Proliferation
por: Liu, Yun-zi, et al.
Publicado: (2021)

Isoform Switch of Pyruvate Kinase M1 Indeed Occurs but Not to Pyruvate Kinase M2 in Human Tumorigenesis
por: Zhan, Cheng, et al.
Publicado: (2015)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

An optimized desuccinylase activity assay reveals a difference in desuccinylation activity between proliferative and differentiated cells
por: Yuan, Taolin, et al.
Publicado: (2020)

Protein kinase function of pyruvate kinase M2 and cancer
por: Chen, Xun, et al.
Publicado: (2020)

Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1
por: Xia, Qian, et al.
Publicado: (2022)

Core-predominant gut fungus Kazachstania slooffiae promotes intestinal epithelial glycolysis via lysine desuccinylation in pigs
por: Hu, Jun, et al.
Publicado: (2023)

An open, observational, three-arm clinical study of 2–3 cycles of treatment as neoadjuvant therapy in operable locally advanced non-small cell lung cancer: An interim analysis
por: Gu, Linping, et al.
Publicado: (2022)

Activator-Mediated Pyruvate Kinase M2 Activation Contributes to Endotoxin Tolerance by Promoting Mitochondrial Biogenesis
por: Yi, Zhujun, et al.
Publicado: (2021)

Pyruvate Kinase M2 Contributes to TLR-Mediated Inflammation and Autoimmunity by Promoting Pyk2 Activation
por: Zhang, Xin, et al.
Publicado: (2021)

Pyruvate kinase M2 modification by a lipid peroxidation byproduct acrolein contributes to kidney fibrosis
por: Kuo, Chin-Wei, et al.
Publicado: (2023)

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma
por: Mukherjee, Joydeep, et al.
Publicado: (2013)

Design and implementation of a mobile system for lung cancer patient follow-up in China and initial report of the ongoing patient registry
por: Ye, Xiangyun, et al.
Publicado: (2016)

Role of isoenzyme M2 of pyruvate kinase in urothelial tumorigenesis
por: Zhou, Haiping, et al.
Publicado: (2016)

The role of pyruvate kinase M2 in anticancer therapeutic treatments
por: Su, Qiongli, et al.
Publicado: (2019)

Upregulation of pyruvate kinase M2 expression by fatty acid synthase contributes to gemcitabine resistance in pancreatic cancer
por: Tian, Shenghua, et al.
Publicado: (2018)

Association of Phosphorylated Pyruvate Dehydrogenase with Pyruvate Kinase M2 Promotes PKM2 Stability in Response to Insulin
por: Hossain, Abu Jubayer, et al.
Publicado: (2023)

Nuclear pyruvate kinase M2 complex serves as a transcriptional coactivator of arylhydrocarbon receptor
por: Matsuda, Shun, et al.
Publicado: (2016)

Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma
por: Wang, Guiping, et al.
Publicado: (2020)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

Pyruvate Kinase M2: A Potential Target for Regulating Inflammation
por: Alves-Filho, Jose C., et al.
Publicado: (2016)

Pyruvate kinase M2 regulates photoreceptor structure, function, and viability
por: Rajala, Ammaji, et al.
Publicado: (2018)

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer
por: Prakasam, Gopinath, et al.
Publicado: (2018)

An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor
por: Yuan, Meng, et al.
Publicado: (2018)

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation
por: Mitchell, Alice Rose, et al.
Publicado: (2018)

The Multifarious Functions of Pyruvate Kinase M2 in Oral Cancer Cells
por: Kurihara-Shimomura, Miyako, et al.
Publicado: (2018)

Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP
por: Choi, Hae-Seul, et al.
Publicado: (2020)

Pyruvate kinase M1 regulates butyrate metabolism in cancerous colonocytes
por: Park, Bohye, et al.
Publicado: (2022)

Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma
por: Davidson, Shawn M., et al.
Publicado: (2022)

High Expression of Pyruvate Kinase M2 is Associated with Chemosensitivity to Epirubicin and 5-Fluorouracil in Breast Cancer
por: Lin, Yang, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_ulhna8hiv6n3p0t1f4crpob7kl