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Chromothripsis and progression-free survival in metastatic colorectal cancer
Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, prog...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351707/ https://www.ncbi.nlm.nih.gov/pubmed/28357089 http://dx.doi.org/10.3892/mco.2017.1123 |
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author | Skuja, Elina Kalniete, Dagnija Nakazawa-Miklasevica, Miki Daneberga, Zanda Abolins, Arnis Purkalne, Gunta Miklasevics, Edvins |
author_facet | Skuja, Elina Kalniete, Dagnija Nakazawa-Miklasevica, Miki Daneberga, Zanda Abolins, Arnis Purkalne, Gunta Miklasevics, Edvins |
author_sort | Skuja, Elina |
collection | PubMed |
description | Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromothripsis and total breakpoint count (breakpoint instability index) on progression-free survival (PFS). A total of 19 patients with metastatic CRC (mCRC) receiving FOLFOX first-line palliative chemotherapy between August, 2011 and October, 2012 were selected for this study. The results indicated that the highest breakpoint count was observed in chromosomes 1, 2 and 6. Chromothripsis was detected in 52.6% of the study patients. Furthermore, chromothripsis was associated with an increased median PFS (mPFS; 14 vs. 8 months, respectively; P=0.03), but an association with overall survival was not identified. The present study demonstrated that chromothripsis affected CRC patient survival, suggesting a role for this event as a prognostic and predictive marker in mCRC treatment. |
format | Online Article Text |
id | pubmed-5351707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-53517072017-03-29 Chromothripsis and progression-free survival in metastatic colorectal cancer Skuja, Elina Kalniete, Dagnija Nakazawa-Miklasevica, Miki Daneberga, Zanda Abolins, Arnis Purkalne, Gunta Miklasevics, Edvins Mol Clin Oncol Articles Metastatic dissemination of the primary tumor is the major cause of death in colorectal cancer (CRC) patients. Multiple chromosomal breaks and chromothripsis, a phenomenon involving multiple chromosomal fragmentations occurring in a single catastrophic event, are associated with cancer genesis, progression and developing of metastases. The aim of this study was to evaluate the effect of chromothripsis and total breakpoint count (breakpoint instability index) on progression-free survival (PFS). A total of 19 patients with metastatic CRC (mCRC) receiving FOLFOX first-line palliative chemotherapy between August, 2011 and October, 2012 were selected for this study. The results indicated that the highest breakpoint count was observed in chromosomes 1, 2 and 6. Chromothripsis was detected in 52.6% of the study patients. Furthermore, chromothripsis was associated with an increased median PFS (mPFS; 14 vs. 8 months, respectively; P=0.03), but an association with overall survival was not identified. The present study demonstrated that chromothripsis affected CRC patient survival, suggesting a role for this event as a prognostic and predictive marker in mCRC treatment. D.A. Spandidos 2017-02 2017-01-02 /pmc/articles/PMC5351707/ /pubmed/28357089 http://dx.doi.org/10.3892/mco.2017.1123 Text en Copyright: © Skuja et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles Skuja, Elina Kalniete, Dagnija Nakazawa-Miklasevica, Miki Daneberga, Zanda Abolins, Arnis Purkalne, Gunta Miklasevics, Edvins Chromothripsis and progression-free survival in metastatic colorectal cancer |
title | Chromothripsis and progression-free survival in metastatic colorectal cancer |
title_full | Chromothripsis and progression-free survival in metastatic colorectal cancer |
title_fullStr | Chromothripsis and progression-free survival in metastatic colorectal cancer |
title_full_unstemmed | Chromothripsis and progression-free survival in metastatic colorectal cancer |
title_short | Chromothripsis and progression-free survival in metastatic colorectal cancer |
title_sort | chromothripsis and progression-free survival in metastatic colorectal cancer |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351707/ https://www.ncbi.nlm.nih.gov/pubmed/28357089 http://dx.doi.org/10.3892/mco.2017.1123 |
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