Anticancer activity of a novel small molecule tubulin inhibitor STK899704

We have identified the small molecule STK899704 as a structurally novel tubulin inhibitor. STK899704 suppressed the proliferation of cancer cell lines from various origins with IC(50) values ranging from 0.2 to 1.0 μM. STK899704 prevented the polymerization of purified tubulin in vitro and also depo...

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Detalles Bibliográficos
Autores principales: Sakchaisri, Krisada, Kim, Sun-Ok, Hwang, Joonsung, Soung, Nak Kyun, Lee, Kyung Ho, Choi, Tae Woong, Lee, Yongjun, Park, Chan-Mi, Thimmegowda, Naraganahalli R., Lee, Phil Young, Shwetha, Bettaswamigowda, Srinivasrao, Ganipisetti, Pham, Thi Thu Huong, Jang, Jae-Hyuk, Yum, Hye-Won, Surh, Young-Joon, Lee, Kyung S., Park, Hwangseo, Kim, Seung Jun, Kwon, Yong Tae, Ahn, Jong Seog, Kim, Bo Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351965/
https://www.ncbi.nlm.nih.gov/pubmed/28296906
http://dx.doi.org/10.1371/journal.pone.0173311

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