Soluble insulin analogs combining rapid- and long-acting hypoglycemic properties – From an efficient E. coli expression system to a pharmaceutical formulation

The discovery of insulin led to a revolution in diabetes management. Since then, many improvements have been introduced to insulin preparations. The availability of molecular genetic techniques has enabled the creation of insulin analogs by changing the structure of the native protein in order to im...

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Detalles Bibliográficos
Autores principales: Mikiewicz, Diana, Bierczyńska-Krzysik, Anna, Sobolewska, Agnieszka, Stadnik, Dorota, Bogiel, Monika, Pawłowska, Monika, Wójtowicz-Krawiec, Anna, Baran, Piotr A., Łukasiewicz, Natalia, Romanik-Chruścielewska, Agnieszka, Sokołowska, Iwona, Stadnik, Jacek, Borowicz, Piotr, Płucienniczak, Grażyna, Płucienniczak, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351984/
https://www.ncbi.nlm.nih.gov/pubmed/28296883
http://dx.doi.org/10.1371/journal.pone.0172600

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