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Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain

Polo-like kinase 1 (Plk1) is a promising target for cancer therapy due to its essential role in cell division. In addition to a highly conserved kinase domain, Plk1 also contains a Polo-Box domain (PBD), which is essential for Plk1's subcellular localization and mitotic functions. We adopted a...

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Detalles Bibliográficos
Autores principales:	Chen, Yunyu, Zhang, Jing, Li, Dongsheng, Jiang, Jiandong, Wang, Yanchang, Si, Shuyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352051/ https://www.ncbi.nlm.nih.gov/pubmed/27902479 http://dx.doi.org/10.18632/oncotarget.13603

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