Cargando…

Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment

Culture of cancerous cells in standard monolayer conditions poorly mirrors growth in three-dimensional architectures typically observed in a wide majority of cancers of different histological origin. Multicellular tumor spheroid (MCTS) culture models were developed to mimic these features. However,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Däster, Silvio, Amatruda, Nunzia, Calabrese, Diego, Ivanek, Robert, Turrini, Eleonora, Droeser, Raoul A., Zajac, Paul, Fimognari, Carmela, Spagnoli, Giulio C., Iezzi, Giandomenica, Mele, Valentina, Muraro, Manuele G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352092/ https://www.ncbi.nlm.nih.gov/pubmed/27965457 http://dx.doi.org/10.18632/oncotarget.13857

Ejemplares similares

Mesenchymal stromal cells induce epithelial-to-mesenchymal transition in human colorectal cancer cells through the expression of surface-bound TGF-β
por: Mele, Valentina, et al.
Publicado: (2014)

IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
por: Droeser, Raoul André, et al.
Publicado: (2021)

OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer
por: Weixler, Benjamin, et al.
Publicado: (2015)

Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells
por: Mele, Valentina, et al.
Publicado: (2022)

Colorectal carcinoma infiltration by myeloperoxidase-expressing neutrophil granulocytes is associated with favorable prognosis
por: Hirt, Christian, et al.
Publicado: (2013)

TIA-1 Cytotoxic Granule-Associated RNA Binding Protein Improves the Prognostic Performance of CD8 in Mismatch Repair-Proficient Colorectal Cancer
por: Zlobec, Inti, et al.
Publicado: (2010)

Hemidesmus indicus induces immunogenic death in human colorectal cancer cells
por: Turrini, Eleonora, et al.
Publicado: (2018)

High Frequency of CD8 Positive Lymphocyte Infiltration Correlates with Lack of Lymph Node Involvement in Early Rectal Cancer
por: Däster, Silvio, et al.
Publicado: (2014)

A replication-incompetent CD154/40L recombinant vaccinia virus induces direct and macrophage-mediated antitumor effects in vitro and in vivo
por: Governa, Valeria, et al.
Publicado: (2019)

Unsuccessful mitosis in multicellular tumour spheroids
por: Molla, Annie, et al.
Publicado: (2017)

Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy
por: Turrini, Eleonora, et al.
Publicado: (2015)

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine
por: Turrini, Eleonora, et al.
Publicado: (2020)

Effect of the Marine Polyketide Plocabulin on Tumor Progression
por: Turrini, Eleonora, et al.
Publicado: (2022)

Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
por: Turrini, Eleonora, et al.
Publicado: (2023)

MAGE-A Antigens and Cancer Immunotherapy
por: Zajac, Paul, et al.
Publicado: (2017)

Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects
por: Calcabrini, Cinzia, et al.
Publicado: (2020)

Marine Anthraquinones: Pharmacological and Toxicological Issues
por: Greco, Giulia, et al.
Publicado: (2021)

Low Expression of Programmed Death 1 (PD-1), PD-1 Ligand 1 (PD-L1), and Low CD8+ T Lymphocyte Infiltration Identify a Subgroup of Patients With Gastric and Esophageal Adenocarcinoma With Severe Prognosis
por: Däster, Silvio, et al.
Publicado: (2020)

Resistance to vincristine of human cells grown as multicellular spheroids.
por: Wibe, E.
Publicado: (1980)

Increased nanoparticle penetration in collagenase-treated multicellular spheroids
por: Goodman, Thomas T, et al.
Publicado: (2007)

Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids
por: Kamatar, Advika, et al.
Publicado: (2020)

Challenges of applying multicellular tumor spheroids in preclinical phase
por: Han, Se Jik, et al.
Publicado: (2021)

Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective
por: Rossi, Martina, et al.
Publicado: (2022)

Protocol for generation of multicellular spheroids through reduced gravity
por: Zinn, Dylan A., et al.
Publicado: (2023)

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids
por: Rusz, Mate, et al.
Publicado: (2019)

The hyaluronan-mediated motility receptor RHAMM promotes growth, invasiveness and dissemination of colorectal cancer
por: Mele, Valentina, et al.
Publicado: (2017)

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids.
por: Mueller-Klieser, W., et al.
Publicado: (1986)

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier
por: Urich, Eduard, et al.
Publicado: (2013)

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device
por: Ayuso, Jose M., et al.
Publicado: (2015)

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids
por: Onozato, Yusuke, et al.
Publicado: (2017)

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
por: Lee, Kwang-Ho, et al.
Publicado: (2021)

Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis
por: Vakhrushev, Igor V., et al.
Publicado: (2021)

Applications and Advances of Multicellular Tumor Spheroids: Challenges in Their Development and Analysis
por: Mitrakas, Achilleas G., et al.
Publicado: (2023)

Marine Sponge Natural Products with Anticancer Potential: An Updated Review
por: Calcabrini, Cinzia, et al.
Publicado: (2017)

Overview of the Anticancer Profile of Avenanthramides from Oat
por: Turrini, Eleonora, et al.
Publicado: (2019)

Janus Kinase Inhibitors and Coronavirus Disease (COVID)-19: Rationale, Clinical Evidence and Safety Issues
por: Gatti, Milo, et al.
Publicado: (2021)

Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs.
por: Morgan, J. E., et al.
Publicado: (1981)

Radiation response of proliferating and quiescent subpopulations isolated from multicellular spheroids.
por: Luk, C. K., et al.
Publicado: (1986)

Cannot write session to /tmp/vufind_sessions/sess_rkfp5ocdl7obiiqin8jsmsm8ri