Cargando…
Kras mutations increase telomerase activity and targeting telomerase is a promising therapeutic strategy for Kras-mutant NSCLC
As shortened telomeres inhibit tumor formation and prolong life span in a Kras(G12D) mouse lung cancer model, we investigated the implications of telomerase in Kras-mutant NSCLC. We found that Kras mutations increased TERT (telomerase reverse transcriptase) mRNA expression and telomerase activity an...
Autores principales: | Liu, Weiran, Yin, Yuesong, Wang, Jun, Shi, Bowen, Zhang, Lianmin, Qian, Dong, Li, Chenguang, Zhang, Hua, Wang, Shengguang, Zhu, Jinfang, Gao, Liuwei, Zhang, Qiang, Jia, Bin, Hao, Ligang, Wang, Changli, Zhang, Bin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352098/ https://www.ncbi.nlm.nih.gov/pubmed/27329725 http://dx.doi.org/10.18632/oncotarget.10162 |
Ejemplares similares
-
Prognostic Value Analysis of Mutational and Clinicopathological Factors in Non-Small Cell Lung Cancer
por: Li, Chenguang, et al.
Publicado: (2014) -
Treating KRAS-mutant NSCLC: latest evidence and clinical consequences
por: Garrido, Pilar, et al.
Publicado: (2017) -
Targeting Mutant KRAS in Pancreatic Cancer: Futile or Promising?
por: Nollmann, Friederike Inga, et al.
Publicado: (2020) -
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
por: Xu, Ke, et al.
Publicado: (2019) -
PinX1 Is a Potential Prognostic Factor for Non-Small-Cell Lung Cancer and Inhibits Cell Proliferation and Migration
por: Wang, Shengguang, et al.
Publicado: (2017)