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Sirtuins in glucose and lipid metabolism
Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian sirtuins family, including SIRT1~7, is involved in many biological processes such as cell survival, proliferation, senescence...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352102/ https://www.ncbi.nlm.nih.gov/pubmed/27659520 http://dx.doi.org/10.18632/oncotarget.12157 |
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author | Ye, Xin Li, Meiting Hou, Tianyun Gao, Tian Zhu, Wei-guo Yang, Yang |
author_facet | Ye, Xin Li, Meiting Hou, Tianyun Gao, Tian Zhu, Wei-guo Yang, Yang |
author_sort | Ye, Xin |
collection | PubMed |
description | Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian sirtuins family, including SIRT1~7, is involved in many biological processes such as cell survival, proliferation, senescence, stress response, genome stability and metabolism. Evidence accumulated over the past two decades has indicated that sirtuins not only serve as important energy status sensors but also protect cells against metabolic stresses. In this review, we summarize the background of glucose and lipid metabolism concerning sirtuins and discuss the functions of sirtuins in glucose and lipid metabolism. We also seek to highlight the biological roles of certain sirtuins members in cancer metabolism. |
format | Online Article Text |
id | pubmed-5352102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53521022017-04-13 Sirtuins in glucose and lipid metabolism Ye, Xin Li, Meiting Hou, Tianyun Gao, Tian Zhu, Wei-guo Yang, Yang Oncotarget Review Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian sirtuins family, including SIRT1~7, is involved in many biological processes such as cell survival, proliferation, senescence, stress response, genome stability and metabolism. Evidence accumulated over the past two decades has indicated that sirtuins not only serve as important energy status sensors but also protect cells against metabolic stresses. In this review, we summarize the background of glucose and lipid metabolism concerning sirtuins and discuss the functions of sirtuins in glucose and lipid metabolism. We also seek to highlight the biological roles of certain sirtuins members in cancer metabolism. Impact Journals LLC 2016-09-21 /pmc/articles/PMC5352102/ /pubmed/27659520 http://dx.doi.org/10.18632/oncotarget.12157 Text en Copyright: © 2017 Ye et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Ye, Xin Li, Meiting Hou, Tianyun Gao, Tian Zhu, Wei-guo Yang, Yang Sirtuins in glucose and lipid metabolism |
title | Sirtuins in glucose and lipid metabolism |
title_full | Sirtuins in glucose and lipid metabolism |
title_fullStr | Sirtuins in glucose and lipid metabolism |
title_full_unstemmed | Sirtuins in glucose and lipid metabolism |
title_short | Sirtuins in glucose and lipid metabolism |
title_sort | sirtuins in glucose and lipid metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352102/ https://www.ncbi.nlm.nih.gov/pubmed/27659520 http://dx.doi.org/10.18632/oncotarget.12157 |
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