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Deletion of 8p is an independent prognostic parameter in prostate cancer
Deletion of chromosome 8p is the second most frequent genomic alteration in prostate cancer. To better understand its clinical significance, 8p deletion was analyzed by fluorescence in-situ hybridization on a prostate cancer tissue microarray. 8p deletion was found in 2,581 of 7,017 cancers (36.8%),...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352127/ https://www.ncbi.nlm.nih.gov/pubmed/27880722 http://dx.doi.org/10.18632/oncotarget.13425 |
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author | Kluth, Martina Amschler, Nina Nadine Galal, Rami Möller-Koop, Christina Barrow, Phillipp Tsourlakis, Maria Christina Jacobsen, Frank Hinsch, Andrea Wittmer, Corinna Steurer, Stefan Krech, Till Büscheck, Franziska Clauditz, Till Sebastian Beyer, Burkhard Wilczak, Waldemar Graefen, Markus Huland, Hartwig Minner, Sarah Schlomm, Thorsten Sauter, Guido Simon, Ronald |
author_facet | Kluth, Martina Amschler, Nina Nadine Galal, Rami Möller-Koop, Christina Barrow, Phillipp Tsourlakis, Maria Christina Jacobsen, Frank Hinsch, Andrea Wittmer, Corinna Steurer, Stefan Krech, Till Büscheck, Franziska Clauditz, Till Sebastian Beyer, Burkhard Wilczak, Waldemar Graefen, Markus Huland, Hartwig Minner, Sarah Schlomm, Thorsten Sauter, Guido Simon, Ronald |
author_sort | Kluth, Martina |
collection | PubMed |
description | Deletion of chromosome 8p is the second most frequent genomic alteration in prostate cancer. To better understand its clinical significance, 8p deletion was analyzed by fluorescence in-situ hybridization on a prostate cancer tissue microarray. 8p deletion was found in 2,581 of 7,017 cancers (36.8%), and was linked to unfavorable tumor phenotype. 8p deletion increased from 29.5% in 4,456 pT2 and 47.8% in 1,598 pT3a to 53.0% in 931 pT3b-pT4 cancers (P < 0,0001). Deletions of 8p were detected in 25.5% of 1,653 Gleason ≤ 3 + 3, 36.6% of 3,880 Gleason 3 + 4, 50.2% of 1,090 Gleason 4 + 3, and 51.1% of 354 Gleason ≥ 4 + 4 tumors (P < 0,0001). 8p deletions were strongly linked to biochemical recurrence (P < 0.0001) independently from established pre- and postoperative prognostic factors (P = 0.0100). However, analysis of morphologically defined subgroups revealed, that 8p deletion lacked prognostic significance in subgroups with very good (Gleason ≤ 3 + 3, 3 + 4 with ≤ 5% Gleason 4) or very poor prognosis (pT3b, Gleason ≥ 8, pN1). 8p deletions were markedly more frequent in cancers with (53.5%) than without PTEN deletions (36.4%; P < 0,0001) and were slightly more frequent in ERG-positive (40.9%) than in ERG-negative cancers (34.7%, P < 0.0001) due to the association with the ERG-associated PTEN deletion. Cancers with 8p/PTEN co-deletions had a strikingly worse prognosis than cancers with deletion of PTEN or 8p alone (P ≤ 0.0003). In summary, 8p deletion is an independent prognostic parameter in prostate cancer that may act synergistically with PTEN deletions. Even statistically independent prognostic biomarkers like 8p may have limited clinical impact in morphologically well defined high or low risk cancers. |
format | Online Article Text |
id | pubmed-5352127 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53521272017-04-13 Deletion of 8p is an independent prognostic parameter in prostate cancer Kluth, Martina Amschler, Nina Nadine Galal, Rami Möller-Koop, Christina Barrow, Phillipp Tsourlakis, Maria Christina Jacobsen, Frank Hinsch, Andrea Wittmer, Corinna Steurer, Stefan Krech, Till Büscheck, Franziska Clauditz, Till Sebastian Beyer, Burkhard Wilczak, Waldemar Graefen, Markus Huland, Hartwig Minner, Sarah Schlomm, Thorsten Sauter, Guido Simon, Ronald Oncotarget Research Paper Deletion of chromosome 8p is the second most frequent genomic alteration in prostate cancer. To better understand its clinical significance, 8p deletion was analyzed by fluorescence in-situ hybridization on a prostate cancer tissue microarray. 8p deletion was found in 2,581 of 7,017 cancers (36.8%), and was linked to unfavorable tumor phenotype. 8p deletion increased from 29.5% in 4,456 pT2 and 47.8% in 1,598 pT3a to 53.0% in 931 pT3b-pT4 cancers (P < 0,0001). Deletions of 8p were detected in 25.5% of 1,653 Gleason ≤ 3 + 3, 36.6% of 3,880 Gleason 3 + 4, 50.2% of 1,090 Gleason 4 + 3, and 51.1% of 354 Gleason ≥ 4 + 4 tumors (P < 0,0001). 8p deletions were strongly linked to biochemical recurrence (P < 0.0001) independently from established pre- and postoperative prognostic factors (P = 0.0100). However, analysis of morphologically defined subgroups revealed, that 8p deletion lacked prognostic significance in subgroups with very good (Gleason ≤ 3 + 3, 3 + 4 with ≤ 5% Gleason 4) or very poor prognosis (pT3b, Gleason ≥ 8, pN1). 8p deletions were markedly more frequent in cancers with (53.5%) than without PTEN deletions (36.4%; P < 0,0001) and were slightly more frequent in ERG-positive (40.9%) than in ERG-negative cancers (34.7%, P < 0.0001) due to the association with the ERG-associated PTEN deletion. Cancers with 8p/PTEN co-deletions had a strikingly worse prognosis than cancers with deletion of PTEN or 8p alone (P ≤ 0.0003). In summary, 8p deletion is an independent prognostic parameter in prostate cancer that may act synergistically with PTEN deletions. Even statistically independent prognostic biomarkers like 8p may have limited clinical impact in morphologically well defined high or low risk cancers. Impact Journals LLC 2016-11-17 /pmc/articles/PMC5352127/ /pubmed/27880722 http://dx.doi.org/10.18632/oncotarget.13425 Text en Copyright: © 2017 Kluth et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kluth, Martina Amschler, Nina Nadine Galal, Rami Möller-Koop, Christina Barrow, Phillipp Tsourlakis, Maria Christina Jacobsen, Frank Hinsch, Andrea Wittmer, Corinna Steurer, Stefan Krech, Till Büscheck, Franziska Clauditz, Till Sebastian Beyer, Burkhard Wilczak, Waldemar Graefen, Markus Huland, Hartwig Minner, Sarah Schlomm, Thorsten Sauter, Guido Simon, Ronald Deletion of 8p is an independent prognostic parameter in prostate cancer |
title | Deletion of 8p is an independent prognostic parameter in prostate cancer |
title_full | Deletion of 8p is an independent prognostic parameter in prostate cancer |
title_fullStr | Deletion of 8p is an independent prognostic parameter in prostate cancer |
title_full_unstemmed | Deletion of 8p is an independent prognostic parameter in prostate cancer |
title_short | Deletion of 8p is an independent prognostic parameter in prostate cancer |
title_sort | deletion of 8p is an independent prognostic parameter in prostate cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352127/ https://www.ncbi.nlm.nih.gov/pubmed/27880722 http://dx.doi.org/10.18632/oncotarget.13425 |
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