Cargando…

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism

Kaposi’s Sarcoma associated Herpesvirus (KSHV), an oncogenic, human gamma-herpesvirus, is the etiological agent of Kaposi’s Sarcoma the most common tumor of AIDS patients world-wide. KSHV is predominantly latent in the main KS tumor cell, the spindle cell, a cell of endothelial origin. KSHV modulate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sychev, Zoi E., Hu, Alex, DiMaio, Terri A., Gitter, Anthony, Camp, Nathan D., Noble, William S., Wolf-Yadlin, Alejandro, Lagunoff, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352148/ https://www.ncbi.nlm.nih.gov/pubmed/28257516 http://dx.doi.org/10.1371/journal.ppat.1006256

Ejemplares similares

KSHV Induction of Angiogenic and Lymphangiogenic Phenotypes
por: DiMaio, Terri A., et al.
Publicado: (2012)

Latent KSHV Infection of Endothelial Cells Induces Integrin Beta3 to Activate Angiogenic Phenotypes
por: DiMaio, Terri A., et al.
Publicado: (2011)

KSHV requires vCyclin to overcome replicative senescence in primary human lymphatic endothelial cells
por: DiMaio, Terri A., et al.
Publicado: (2020)

Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells
por: Bruce, A. Gregory, et al.
Publicado: (2017)

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi’s sarcoma studies
por: Tuohinto, Krista, et al.
Publicado: (2023)

Latent KSHV Infected Endothelial Cells Are Glutamine Addicted and Require Glutaminolysis for Survival
por: Sanchez, Erica L., et al.
Publicado: (2015)

Global Metabolic Profiling of Infection by an Oncogenic Virus: KSHV Induces and Requires Lipogenesis for Survival of Latent Infection
por: Delgado, Tracie, et al.
Publicado: (2012)

KSHV Topologically Associating Domains in Latent and Reactivated Viral Chromatin
por: Campbell, Mel, et al.
Publicado: (2022)

Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis
por: Moore, Lyndsey N., et al.
Publicado: (2023)

Latently KSHV-Infected Cells Promote Further Establishment of Latency upon Superinfection with KSHV
por: Gam ze Letova, Chen, et al.
Publicado: (2021)

A Viral Genome Landscape of RNA Polyadenylation from KSHV Latent to Lytic Infection
por: Majerciak, Vladimir, et al.
Publicado: (2013)

Epigenetic Analysis of KSHV Latent and Lytic Genomes
por: Toth, Zsolt, et al.
Publicado: (2010)

Technical advances in proteomics: new developments in data-independent acquisition
por: Hu, Alex, et al.
Publicado: (2016)

Virally encoded interleukin-6 facilitates KSHV replication in monocytes and induction of dysfunctional macrophages
por: Shimoda, Michiko, et al.
Publicado: (2023)

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation
por: Olson, Annabel T., et al.
Publicado: (2023)

The landscape of transcription initiation across latent and lytic KSHV genomes
por: Ye, Xiang, et al.
Publicado: (2019)

Polypharmacology-based kinome screen identifies new regulators of KSHV reactivation
por: Olson, Annabel T., et al.
Publicado: (2023)

KSHV Rta Promoter Specification and Viral Reactivation
por: Guito, Jonathan, et al.
Publicado: (2012)

Using stable isotopes in hummingbird breath to estimate reliance on supplemental feeders
por: Wolf, Nathan, et al.
Publicado: (2023)

Transient induction of lytic Kaposi's sarcoma-associated herpesvirus (KSHV) genes in KSHV-infected endothelial cells exposed to hypoxia
por: Velasco, P, et al.
Publicado: (2009)

The Viral Interferon Regulatory Factors of KSHV: Immunosuppressors or Oncogenes?
por: Jacobs, Sarah R., et al.
Publicado: (2011)

Emmprin and KSHV: New partners in viral cancer pathogenesis
por: Dai, Lu, et al.
Publicado: (2013)

Interpretability and reliance on simulation
por: Nachman, Ben
Publicado: (2020)

Self-reliance : a strategy for development /
Publicado: (1980)

Inhibition of Tip60 Reduces Lytic and Latent Gene Expression of Kaposi’s Sarcoma-Associated Herpes Virus (KSHV) and Proliferation of KSHV-Infected Tumor Cells
por: Simpson, Sydney, et al.
Publicado: (2018)

KSHV LANA—The Master Regulator of KSHV Latency
por: Uppal, Timsy, et al.
Publicado: (2014)

Polyamine biosynthesis and eIF5A hypusination are modulated by the DNA tumor virus KSHV and promote KSHV viral infection
por: Fiches, Guillaume N., et al.
Publicado: (2022)

Coordination of KSHV Latent and Lytic Gene Control by CTCF-Cohesin Mediated Chromosome Conformation
por: Kang, Hyojeung, et al.
Publicado: (2011)

G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV
por: Madireddy, Advaitha, et al.
Publicado: (2016)

Synthesizing Signaling Pathways from Temporal Phosphoproteomic Data
por: Kӧksal, Ali Sinan, et al.
Publicado: (2018)

Contribution of Viral Mimics of Cellular Genes to KSHV Infection and Disease
por: Sakakibara, Shuhei, et al.
Publicado: (2014)

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication
por: Coen, Natacha, et al.
Publicado: (2014)

Chromatinization of the KSHV Genome During the KSHV Life Cycle
por: Uppal, Timsy, et al.
Publicado: (2015)

The Role of Bacteria in KSHV Infection and KSHV-Induced Cancers
por: Markazi, Ashley, et al.
Publicado: (2021)

Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines
por: Kang, Hyunju, et al.
Publicado: (2014)

Glutamine reliance in cell metabolism
por: Yoo, Hee Chan, et al.
Publicado: (2020)

Disrupting Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) Latent Replication with a Small Molecule Inhibitor
por: Berwanger, Aylin, et al.
Publicado: (2023)

KSHV activation, human and viral IL-6 production, and other cytokine dysregulation: Association with the symptomatology of KSHV-associated multicentric Castleman’s disease
por: Polizzotto, Mark N, et al.
Publicado: (2010)

Inductive generalization with familiar categories: developmental changes in children's reliance on perceptual similarity and kind information
por: Godwin, Karrie E., et al.
Publicado: (2015)

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
por: Romeo, Maria Anele, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_efpop119g1shc7v22ovbsluuha