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Inhibition of BCR signaling using the Syk inhibitor TAK-659 prevents stroma-mediated signaling in chronic lymphocytic leukemia cells

Proliferation and survival of chronic lymphocytic leukemia (CLL) cells depend on microenvironmental signals coming from lymphoid organs. One of the key players involved in the crosstalk between CLL cells and the microenvironment is the B-cell receptor (BCR). Syk protein, a tyrosine kinase essential...

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Detalles Bibliográficos
Autores principales:	Purroy, Noelia, Carabia, Júlia, Abrisqueta, Pau, Egia, Leire, Aguiló, Meritxell, Carpio, Cecilia, Palacio, Carles, Crespo, Marta, Bosch, Francesc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352193/ https://www.ncbi.nlm.nih.gov/pubmed/27888629 http://dx.doi.org/10.18632/oncotarget.13557

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