DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway

Hedgehog (Hh) signaling plays important roles in embryonic development and in tumor formation. Apart from the well-established stimulation of the GLI family of transcription factors, Hh ligands promote the phosphorylation and activation of mTOR and AKT kinases, yet the molecular mechanism underlying...

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Detalles Bibliográficos
Autores principales: Singh, Rajeev, Dhanyamraju, Pavan Kumar, Lauth, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352201/
https://www.ncbi.nlm.nih.gov/pubmed/27903983
http://dx.doi.org/10.18632/oncotarget.13662

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