Unconjugated secondary bile acids activate the unfolded protein response and induce golgi fragmentation via a src-kinase-dependant mechanism

Bile acids are components of gastro-duodenal refluxate and regarded as causative agents in oesophageal disease but the precise mechanisms are unknown. Here we demonstrate that a specific subset of physiological bile acids affect the protein secretory pathway by inducing ER stress, activating the Unf...

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Detalles Bibliográficos
Autores principales: Sharma, Ruchika, Quilty, Francis, Gilmer, John F., Long, Aideen, Byrne, Anne-Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352210/
https://www.ncbi.nlm.nih.gov/pubmed/27888615
http://dx.doi.org/10.18632/oncotarget.13514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352210/
https://www.ncbi.nlm.nih.gov/pubmed/27888615
http://dx.doi.org/10.18632/oncotarget.13514

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