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Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice

During aging, uncontrolled epithelial cell proliferation in the uterus results in endometrial hyperplasia and/or cancer development. The mTOR signaling pathway is one of the major regulators of aging as suppression of this pathway prolongs lifespan in model organisms. Genetic alterations in this pat...

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Detalles Bibliográficos
Autores principales:	Bajwa, Preety, Nielsen, Sarah, Lombard, Janine M., Rassam, Loui, Nahar, Pravin, Rueda, Bo R., Wilkinson, J. Erby, Miller, Richard A., Tanwar, Pradeep S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Priority Research Paper: Gerotarget
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352319/ https://www.ncbi.nlm.nih.gov/pubmed/27980219 http://dx.doi.org/10.18632/oncotarget.13919

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