α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy

Macrophage apoptosis is salient in advanced atherosclerotic lesions and is induced by several stimuli including endoplasmic reticulum (ER) stress. This study examined that a-asarone present in purple perilla abrogated macrophage injury caused by oxysterols via ER stress- and autophagy-mediated mecha...

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Detalles Bibliográficos
Autores principales: Park, Sin-Hye, Kang, Min-Kyung, Choi, Yean-Jung, Kim, Yun-Ho, Antika, Lucia Dwi, Kim, Dong Yeon, Lee, Eun-Jung, Lim, Soon Sung, Kang, Young-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352328/
https://www.ncbi.nlm.nih.gov/pubmed/28088783
http://dx.doi.org/10.18632/oncotarget.14566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352328/
https://www.ncbi.nlm.nih.gov/pubmed/28088783
http://dx.doi.org/10.18632/oncotarget.14566

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