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α-Asarone blocks 7β-hydroxycholesterol-exposed macrophage injury through blocking elF2α phosphorylation and prompting beclin-1-dependent autophagy
Macrophage apoptosis is salient in advanced atherosclerotic lesions and is induced by several stimuli including endoplasmic reticulum (ER) stress. This study examined that a-asarone present in purple perilla abrogated macrophage injury caused by oxysterols via ER stress- and autophagy-mediated mecha...
Autores principales: | Park, Sin-Hye, Kang, Min-Kyung, Choi, Yean-Jung, Kim, Yun-Ho, Antika, Lucia Dwi, Kim, Dong Yeon, Lee, Eun-Jung, Lim, Soon Sung, Kang, Young-Hee |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352328/ https://www.ncbi.nlm.nih.gov/pubmed/28088783 http://dx.doi.org/10.18632/oncotarget.14566 |
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