Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells

Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the c...

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Autores principales: Liang, Ping, Shi, Hongming, Zhu, Weiguo, Gui, Qunfeng, Xu, Ya, Meng, Jianfeng, Guo, Xiaoyuan, Gong, Zhuang, Chen, Huaqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352340/
https://www.ncbi.nlm.nih.gov/pubmed/27893419
http://dx.doi.org/10.18632/oncotarget.13503
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author Liang, Ping
Shi, Hongming
Zhu, Weiguo
Gui, Qunfeng
Xu, Ya
Meng, Jianfeng
Guo, Xiaoyuan
Gong, Zhuang
Chen, Huaqun
author_facet Liang, Ping
Shi, Hongming
Zhu, Weiguo
Gui, Qunfeng
Xu, Ya
Meng, Jianfeng
Guo, Xiaoyuan
Gong, Zhuang
Chen, Huaqun
author_sort Liang, Ping
collection PubMed
description Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the cancer therapeutic effect. In this study, we investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells. AgNPs were synthesized in the sodium citrate system and the mean size were 26 nm in diameter. The AgNP particles showed dose-dependent cytotoxicity on U251 cells. They also showed the ability to enhance the drug-sensitivity of TMZ on U251 cells. Our results revealed that AgNPs could have a potential application in enhancing chemotherapy for glioma.
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spelling pubmed-53523402017-04-14 Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells Liang, Ping Shi, Hongming Zhu, Weiguo Gui, Qunfeng Xu, Ya Meng, Jianfeng Guo, Xiaoyuan Gong, Zhuang Chen, Huaqun Oncotarget Research Paper Glioblastoma multiforme (GBM) continues to be associated with a dismal prognosis despite aggressive treatment. Significant efforts are being made to develop new nanotechnology-based therapeutic and diagnostic agents. Nanoparticles can act directly on cancer cells or as drug carriers to enhance the cancer therapeutic effect. In this study, we investigated the effect of silver nanoparticles (AgNPs) on human glioma U251 cells and its role in the combinational use with Temozolomide (TMZ), an imidazotetrazine derivative of the alkylating agent dacarbazine, against glioma cells. AgNPs were synthesized in the sodium citrate system and the mean size were 26 nm in diameter. The AgNP particles showed dose-dependent cytotoxicity on U251 cells. They also showed the ability to enhance the drug-sensitivity of TMZ on U251 cells. Our results revealed that AgNPs could have a potential application in enhancing chemotherapy for glioma. Impact Journals LLC 2016-11-22 /pmc/articles/PMC5352340/ /pubmed/27893419 http://dx.doi.org/10.18632/oncotarget.13503 Text en Copyright: © 2017 Liang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liang, Ping
Shi, Hongming
Zhu, Weiguo
Gui, Qunfeng
Xu, Ya
Meng, Jianfeng
Guo, Xiaoyuan
Gong, Zhuang
Chen, Huaqun
Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title_full Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title_fullStr Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title_full_unstemmed Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title_short Silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
title_sort silver nanoparticles enhance the sensitivity of temozolomide on human glioma cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352340/
https://www.ncbi.nlm.nih.gov/pubmed/27893419
http://dx.doi.org/10.18632/oncotarget.13503
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