Dual inhibition of the PI3K/AKT/mTOR pathway suppresses the growth of leiomyosarcomas but leads to ERK activation through mTORC2: biological and clinical implications

The PI3K/AKT/mTOR pathway plays a crucial role in the development of leiomyosarcomas (LMSs). In this study, we tested the efficacy of dual PI3K/mTOR (BEZ235), PI3K (BKM120) and mTOR (everolimus) inhibitors in three human LMS cell lines. In vitro and in vivo studies using LMS cell lines showed that B...

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Detalles Bibliográficos
Autores principales: Fourneaux, Benjamin, Chaire, Vanessa, Lucchesi, Carlo, Karanian, Marie, Pineau, Raphael, Laroche-Clary, Audrey, Italiano, Antoine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352367/
https://www.ncbi.nlm.nih.gov/pubmed/28002802
http://dx.doi.org/10.18632/oncotarget.13987

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