Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer

Rap1GAP is a crucial tumor suppressor, but its role in gastric cancer (GC) is little investigated. In this study, we found that the expression of Rap1GAP was decreased in GC. Low expression of Rap1GAP was positively correlated with advanced pTNM stage, Borrmann types, tumor diameter and poor prognos...

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Autores principales: Yang, Ya, Zhang, Jia, Yan, Yan, Cai, Hui, Li, Min, Sun, Kai, Wang, Jizhao, Liu, Xu, Wang, Jiansheng, Duan, Xiaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352382/
https://www.ncbi.nlm.nih.gov/pubmed/28009991
http://dx.doi.org/10.18632/oncotarget.14074
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author Yang, Ya
Zhang, Jia
Yan, Yan
Cai, Hui
Li, Min
Sun, Kai
Wang, Jizhao
Liu, Xu
Wang, Jiansheng
Duan, Xiaoyi
author_facet Yang, Ya
Zhang, Jia
Yan, Yan
Cai, Hui
Li, Min
Sun, Kai
Wang, Jizhao
Liu, Xu
Wang, Jiansheng
Duan, Xiaoyi
author_sort Yang, Ya
collection PubMed
description Rap1GAP is a crucial tumor suppressor, but its role in gastric cancer (GC) is little investigated. In this study, we found that the expression of Rap1GAP was decreased in GC. Low expression of Rap1GAP was positively correlated with advanced pTNM stage, Borrmann types, tumor diameter and poor prognosis in patients with GC. Low expression of Rap1GAP correlated with loss of E-cadherin expression, and anomalous positivity of MMP2 expression. Multivariate analysis showed that low expression of Rap1GAP was an independent prognostic factor. Ectopic expression of Rap1GAP impaired cell migration and invasion, promoted the expression of E-cadherin and decreased the expression of MMP2. These results suggest that Rap1GAP functions as a novel suppressor of EMT and tumor metastasis in GC, and loss of Rap1GAP predicts poor prognosis in GC.
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spelling pubmed-53523822017-04-14 Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer Yang, Ya Zhang, Jia Yan, Yan Cai, Hui Li, Min Sun, Kai Wang, Jizhao Liu, Xu Wang, Jiansheng Duan, Xiaoyi Oncotarget Research Paper Rap1GAP is a crucial tumor suppressor, but its role in gastric cancer (GC) is little investigated. In this study, we found that the expression of Rap1GAP was decreased in GC. Low expression of Rap1GAP was positively correlated with advanced pTNM stage, Borrmann types, tumor diameter and poor prognosis in patients with GC. Low expression of Rap1GAP correlated with loss of E-cadherin expression, and anomalous positivity of MMP2 expression. Multivariate analysis showed that low expression of Rap1GAP was an independent prognostic factor. Ectopic expression of Rap1GAP impaired cell migration and invasion, promoted the expression of E-cadherin and decreased the expression of MMP2. These results suggest that Rap1GAP functions as a novel suppressor of EMT and tumor metastasis in GC, and loss of Rap1GAP predicts poor prognosis in GC. Impact Journals LLC 2016-12-21 /pmc/articles/PMC5352382/ /pubmed/28009991 http://dx.doi.org/10.18632/oncotarget.14074 Text en Copyright: © 2017 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Yang, Ya
Zhang, Jia
Yan, Yan
Cai, Hui
Li, Min
Sun, Kai
Wang, Jizhao
Liu, Xu
Wang, Jiansheng
Duan, Xiaoyi
Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title_full Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title_fullStr Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title_full_unstemmed Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title_short Low expression of Rap1GAP is associated with epithelial-mesenchymal transition (EMT) and poor prognosis in gastric cancer
title_sort low expression of rap1gap is associated with epithelial-mesenchymal transition (emt) and poor prognosis in gastric cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352382/
https://www.ncbi.nlm.nih.gov/pubmed/28009991
http://dx.doi.org/10.18632/oncotarget.14074
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