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ASIC1 promotes differentiation of neuroblastoma by negatively regulating Notch signaling pathway

In neurons, up-regulation of Notch activity either inhibits neurite extension or causes retraction of neurites. Conversely, inhibition of Notch1 facilitates neurite extension. Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels, which play critical roles in synaptic plasti...

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Detalles Bibliográficos
Autores principales: Liu, Mingli, Inoue, Koichi, Leng, Tiandong, Zhou, An, Guo, Shanchun, Xiong, Zhi-gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352400/
https://www.ncbi.nlm.nih.gov/pubmed/28030818
http://dx.doi.org/10.18632/oncotarget.14164

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