BH3 mimetics suppress CXCL12 expression in human malignant peripheral nerve sheath tumor cells

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, Schwann cell-derived neoplasms of the peripheral nervous system that have recently been shown to possess an autocrine CXCL12/CXCR4 signaling loop that promotes tumor cell proliferation and survival. Importantly, the CXCL12/CXCR4 signa...

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Detalles Bibliográficos
Autores principales: Graham, Christopher D., Kaza, Niroop, Pruitt, Hawley C., Gibson, Lauren M., Klocke, Barbara J., Shevde, Lalita A., Carroll, Steven L., Roth, Kevin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352431/
https://www.ncbi.nlm.nih.gov/pubmed/28055968
http://dx.doi.org/10.18632/oncotarget.14398

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