A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test

Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, w...

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Autores principales: Kim, Jakyoung, Park, Shinyoung, Jung, Chul Min, Oh, Chee Won, Kwon, Jae-Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2017
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352581/
https://www.ncbi.nlm.nih.gov/pubmed/28293936
http://dx.doi.org/10.4168/aair.2017.9.3.281
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author Kim, Jakyoung
Park, Shinyoung
Jung, Chul Min
Oh, Chee Won
Kwon, Jae-Woo
author_facet Kim, Jakyoung
Park, Shinyoung
Jung, Chul Min
Oh, Chee Won
Kwon, Jae-Woo
author_sort Kim, Jakyoung
collection PubMed
description Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for the diagnosis of LDE.
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spelling pubmed-53525812017-05-01 A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test Kim, Jakyoung Park, Shinyoung Jung, Chul Min Oh, Chee Won Kwon, Jae-Woo Allergy Asthma Immunol Res Letter to the Editor Lichenoid drug eruption (LDE) is a rare form of delayed-type drug eruption. Among anti-tuberculosis (Tb) agents, cycloserine (CS) has been reported as a rare cause of LDE. Positive results on the lymphocyte transformation test (LTT) have not been reported in patients with LDE. In the present case, we performed LTT and a patch test, and successfully proved CS as the offending drug in this patient, who had been treated with multiple anti-Tb drugs. These observations suggest that CS should be considered a possible cause of LDE and that LTT can be an option for the diagnosis of LDE. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2017-05 2017-01-18 /pmc/articles/PMC5352581/ /pubmed/28293936 http://dx.doi.org/10.4168/aair.2017.9.3.281 Text en Copyright © 2017 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to the Editor
Kim, Jakyoung
Park, Shinyoung
Jung, Chul Min
Oh, Chee Won
Kwon, Jae-Woo
A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title_full A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title_fullStr A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title_full_unstemmed A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title_short A Case of Cycloserine-Induced Lichenoid Drug Eruption Supported by the Lymphocyte Transformation Test
title_sort case of cycloserine-induced lichenoid drug eruption supported by the lymphocyte transformation test
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352581/
https://www.ncbi.nlm.nih.gov/pubmed/28293936
http://dx.doi.org/10.4168/aair.2017.9.3.281
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