The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report

Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken...

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Autores principales: Morita, Mayu, Asoda, Seiji, Tsunoda, Kazuyuki, Soma, Tomoya, Nakagawa, Taneaki, Shirakawa, Masayori, Shoji, Hirofumi, Yagishita, Hisao, Nishikawa, Takeji, Kawana, Hiromasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352802/
https://www.ncbi.nlm.nih.gov/pubmed/27368962
http://dx.doi.org/10.1007/s10266-016-0255-4
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author Morita, Mayu
Asoda, Seiji
Tsunoda, Kazuyuki
Soma, Tomoya
Nakagawa, Taneaki
Shirakawa, Masayori
Shoji, Hirofumi
Yagishita, Hisao
Nishikawa, Takeji
Kawana, Hiromasa
author_facet Morita, Mayu
Asoda, Seiji
Tsunoda, Kazuyuki
Soma, Tomoya
Nakagawa, Taneaki
Shirakawa, Masayori
Shoji, Hirofumi
Yagishita, Hisao
Nishikawa, Takeji
Kawana, Hiromasa
author_sort Morita, Mayu
collection PubMed
description Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus.
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spelling pubmed-53528022017-03-28 The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report Morita, Mayu Asoda, Seiji Tsunoda, Kazuyuki Soma, Tomoya Nakagawa, Taneaki Shirakawa, Masayori Shoji, Hirofumi Yagishita, Hisao Nishikawa, Takeji Kawana, Hiromasa Odontology Case Report Oral lichen planus is a chronic inflammatory mucocutaneous disease. Topical use of steroids and other immuno-modulating therapies have been tried for this intractable condition. Nowadays, tacrolimus ointment is used more commonly as a choice for treatment. However, a number of discussions have taken place after tacrolimus was reported to be carcinogenic. This report describes a patient who applied tacrolimus ointment to the lower lip after being diagnosed with oral lichen planus in 2008, and whose lesion developed squamous cell carcinoma in 2010. Since the relationship between tacrolimus and cancer development has been reported in only a few cases, including this case report, the clinician must be careful selecting tacrolimus as a second-line treatment for oral lichen planus. Springer Japan 2016-07-01 2017 /pmc/articles/PMC5352802/ /pubmed/27368962 http://dx.doi.org/10.1007/s10266-016-0255-4 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Morita, Mayu
Asoda, Seiji
Tsunoda, Kazuyuki
Soma, Tomoya
Nakagawa, Taneaki
Shirakawa, Masayori
Shoji, Hirofumi
Yagishita, Hisao
Nishikawa, Takeji
Kawana, Hiromasa
The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title_full The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title_fullStr The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title_full_unstemmed The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title_short The onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
title_sort onset risk of carcinoma in patients continuing tacrolimus topical treatment for oral lichen planus: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352802/
https://www.ncbi.nlm.nih.gov/pubmed/27368962
http://dx.doi.org/10.1007/s10266-016-0255-4
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