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Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study

PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next...

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Detalles Bibliográficos
Autor principal: Badawi, Amani E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352941/
https://www.ncbi.nlm.nih.gov/pubmed/28337057
http://dx.doi.org/10.1016/j.sjopt.2017.01.002
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author Badawi, Amani E.
author_facet Badawi, Amani E.
author_sort Badawi, Amani E.
collection PubMed
description PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next, riboflavin/hydroxypropyl methylcellulose solution) was applied for 10 min. Accelerated CXL (10 mW/cm(2) for 9 min), was accomplished. Visual acuity, slit lamp examination, refraction, keratometry readings, pachymetry, anterior and posterior elevations, average progression indices, and Q values were recorded. The follow-up visits were scheduled on one day, 3 days, 7 days, one month and then on 3, 6, 12 months after the procedure. RESULTS: It was statistically significant improvement of the mean UAVA, AVA, and the mean corneal astigmatism (P < .0001). The mean corneal thickness showed a significant reduction. The preoperative mean K max reading was reduced from 49.12 ± 3.7 D preoperatively to 47.9 ± 3.7 D at 12 months. The mean max anterior elevation, average progression index and Q value showed statistically significant improvement. No significant impact on posterior elevation was recorded. Serious complications were not encountered in this study. CONCLUSION: Accelerated CXL shows a stabilization and beneficial clinical outcomes in pediatric keratoconus. It seems an effective and safe procedure in this age group. Effects of accelerated CXL on the posterior corneal surface will need further evaluation.
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spelling pubmed-53529412017-03-23 Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study Badawi, Amani E. Saudi J Ophthalmol Original Article PURPOSE: To evaluate the safety and effectiveness of accelerated corneal collagen crosslinking (CXL) in pediatric keratoconus. DESIGN: Prospective non-randomized observational study. METHODS: 33 eyes of 25 children with keratoconus were included. The corneal epithelium was mechanically removed. Next, riboflavin/hydroxypropyl methylcellulose solution) was applied for 10 min. Accelerated CXL (10 mW/cm(2) for 9 min), was accomplished. Visual acuity, slit lamp examination, refraction, keratometry readings, pachymetry, anterior and posterior elevations, average progression indices, and Q values were recorded. The follow-up visits were scheduled on one day, 3 days, 7 days, one month and then on 3, 6, 12 months after the procedure. RESULTS: It was statistically significant improvement of the mean UAVA, AVA, and the mean corneal astigmatism (P < .0001). The mean corneal thickness showed a significant reduction. The preoperative mean K max reading was reduced from 49.12 ± 3.7 D preoperatively to 47.9 ± 3.7 D at 12 months. The mean max anterior elevation, average progression index and Q value showed statistically significant improvement. No significant impact on posterior elevation was recorded. Serious complications were not encountered in this study. CONCLUSION: Accelerated CXL shows a stabilization and beneficial clinical outcomes in pediatric keratoconus. It seems an effective and safe procedure in this age group. Effects of accelerated CXL on the posterior corneal surface will need further evaluation. Elsevier 2017 2017-01-25 /pmc/articles/PMC5352941/ /pubmed/28337057 http://dx.doi.org/10.1016/j.sjopt.2017.01.002 Text en © 2017 The Author http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Badawi, Amani E.
Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title_full Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title_fullStr Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title_full_unstemmed Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title_short Accelerated corneal collagen cross-linking in pediatric keratoconus: One year study
title_sort accelerated corneal collagen cross-linking in pediatric keratoconus: one year study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352941/
https://www.ncbi.nlm.nih.gov/pubmed/28337057
http://dx.doi.org/10.1016/j.sjopt.2017.01.002
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