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Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience

Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. T...

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Autores principales: Buechter, Matthias, Manka, Paul, Heinemann, Falko Markus, Lindemann, Monika, Juntermanns, Benjamin, Canbay, Ali, Gerken, Guido, Kahraman, Alisan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352972/
https://www.ncbi.nlm.nih.gov/pubmed/28348580
http://dx.doi.org/10.1155/2017/6126707
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author Buechter, Matthias
Manka, Paul
Heinemann, Falko Markus
Lindemann, Monika
Juntermanns, Benjamin
Canbay, Ali
Gerken, Guido
Kahraman, Alisan
author_facet Buechter, Matthias
Manka, Paul
Heinemann, Falko Markus
Lindemann, Monika
Juntermanns, Benjamin
Canbay, Ali
Gerken, Guido
Kahraman, Alisan
author_sort Buechter, Matthias
collection PubMed
description Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of patients suffered from AIP1 (55.6%). AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years). Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC). However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4). When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance. Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients. Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC). Conclusion. In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort. AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis.
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spelling pubmed-53529722017-03-27 Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience Buechter, Matthias Manka, Paul Heinemann, Falko Markus Lindemann, Monika Juntermanns, Benjamin Canbay, Ali Gerken, Guido Kahraman, Alisan Gastroenterol Res Pract Research Article Introduction. Most investigations on autoimmune pancreatitis (AIP) were published on Asian cohorts while those on Caucasians are limited. However, there might be differences related to the origin. Patients and Methods. We analyzed 36 patients and compared type 1 (AIP1) with type 2 (AIP2). Results. The majority of patients suffered from AIP1 (55.6%). AIP1 patients were significantly older than AIP2 patients (54.4 versus 40.8 years). Moreover, 85.0% of AIP1 patients had concurrent autoimmune cholangitis (AIC) while 18.8% of AIP2 patients suffered from overlap to ulcerative colitis (UC). However, AIP1 patients revealed a cholestatic course and had significantly higher immunoglobulin G4 levels (IgG4). When compared to allele frequencies in healthy controls, in patients with AIP1 HLA-B8 reached statistical significance. Response to steroids was excellent in both groups, but we noticed high rates of relapse especially in AIP1 patients. Finally, 3 patients with AIP1 were diagnosed with cholangiocellular carcinoma (CCC). Conclusion. In contrast to Asian studies, we found an almost equal distribution of AIP1 and AIP2 patients in our German cohort. AIP2 patients were younger and mostly of female gender whereas AIP1 patients revealed higher IgG4 levels and involvement of the biliary tract in sense of IgG4-associated cholangitis. Hindawi 2017 2017-03-02 /pmc/articles/PMC5352972/ /pubmed/28348580 http://dx.doi.org/10.1155/2017/6126707 Text en Copyright © 2017 Matthias Buechter et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Buechter, Matthias
Manka, Paul
Heinemann, Falko Markus
Lindemann, Monika
Juntermanns, Benjamin
Canbay, Ali
Gerken, Guido
Kahraman, Alisan
Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title_full Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title_fullStr Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title_full_unstemmed Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title_short Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience
title_sort outcome and genetic factors in igg4-associated autoimmune pancreatitis and cholangitis: a single center experience
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352972/
https://www.ncbi.nlm.nih.gov/pubmed/28348580
http://dx.doi.org/10.1155/2017/6126707
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