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Efficacy and safety of lapatinib and trastuzumab for HER2-positive breast cancer: a systematic review and meta-analysis of randomised controlled trials

OBJECTIVES: The anti-HER2 monoclonal antibody trastuzumab and the tyrosine kinase inhibitor lapatinib have complementary mechanisms of action and synergistic antitumour actively in models of HER2-positive breast cancer. However, the efficacy of trastuzumab in combination with lapatinib remains contr...

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Detalles Bibliográficos
Autores principales:	Xu, Zhi-qiao, Zhang, Yan, Li, Ning, Liu, Pei-jie, Gao, Ling, Gao, Xin, Tie, Xiao-jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2017
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353336/ https://www.ncbi.nlm.nih.gov/pubmed/28289045 http://dx.doi.org/10.1136/bmjopen-2016-013053

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