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Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study

CONTEXT: Metabolic syndrome (MS) is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia, associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Although...

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Autores principales: La Carrubba, Salvatore, Todaro, Maria Chiara, Zito, Concetta, Antonini-Canterin, Francesco, Monte, Ines Paola, Caso, Pio, Colonna, Paolo, de Gregorio, Cesare, Pezzano, Antonio, Benedetto, Frank, Salvo, Giovanni Di, Carerj, Scipione, Bello, Vitantonio Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353398/
https://www.ncbi.nlm.nih.gov/pubmed/28465894
http://dx.doi.org/10.4103/2211-4122.127410
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author La Carrubba, Salvatore
Todaro, Maria Chiara
Zito, Concetta
Antonini-Canterin, Francesco
Monte, Ines Paola
Caso, Pio
Colonna, Paolo
de Gregorio, Cesare
Pezzano, Antonio
Benedetto, Frank
Salvo, Giovanni Di
Carerj, Scipione
Bello, Vitantonio Di
author_facet La Carrubba, Salvatore
Todaro, Maria Chiara
Zito, Concetta
Antonini-Canterin, Francesco
Monte, Ines Paola
Caso, Pio
Colonna, Paolo
de Gregorio, Cesare
Pezzano, Antonio
Benedetto, Frank
Salvo, Giovanni Di
Carerj, Scipione
Bello, Vitantonio Di
author_sort La Carrubba, Salvatore
collection PubMed
description CONTEXT: Metabolic syndrome (MS) is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia, associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Although MS is associated with increased cardiovascular risk (CVR), its relationship with heart failure (HF) and left ventricular (LV) dysfunction is not fully understood. AIMS: We sought to determine whether MS is associated to LV systolic and diastolic dysfunction in a sample of patients with MS and no symptoms for HF. SUBJECTS AND METHODS: We enrolled 6422 consecutive asymptomatic patients admitted to echo-lab for a routine echocardiogram. We calculated LV systolic and diastolic function, by Simpson biplane method and validated Doppler parameters, respectively. MS was diagnosed if three or more CVR factors were found. RESULTS: LV systolic function was evaluated in 6175 patients (96.2%). In the group of patients without MS (n = 5630), the prevalence of systolic dysfunction was 10.8% (n = 607) while in the group of patients with MS (n = 545) it was 12.5% (n = 87), (RR1.57; CI 95% 1.2-2.0; P < 0.001). Diastolic function was evaluated in 3936 patients (61.3%). In the group of patients without MS (n = 3566) the prevalence of diastolic dysfunction was 33.3% (n = 1187), while in patients with MS (n = 370) it was 45.7% (n = 169), (RR1.68; CI95% 1.3-2.0; P < 0.001). After adjustment for age and gender, MS proved to be an independent predictor of LV systolic and diastolic dysfunction. CONCLUSIONS: Our data show that asymptomatic LV systolic and diastolic dysfunction, is correlated with MS and demonstrate that echocardiography is a useful tool to detect patients at high risk for HF. Echocardiography in asymptomatic patients with MS may lead to a therapy initiation at early stages to prevent future cardiovascular events and HF.
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spelling pubmed-53533982017-05-02 Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study La Carrubba, Salvatore Todaro, Maria Chiara Zito, Concetta Antonini-Canterin, Francesco Monte, Ines Paola Caso, Pio Colonna, Paolo de Gregorio, Cesare Pezzano, Antonio Benedetto, Frank Salvo, Giovanni Di Carerj, Scipione Bello, Vitantonio Di J Cardiovasc Echogr Original Article CONTEXT: Metabolic syndrome (MS) is a cluster of interrelated common clinical disorders, including obesity, insulin resistance, glucose intolerance, hypertension and dyslipidemia, associated with a greater risk of atherosclerotic cardiovascular disease than any of its individual components. Although MS is associated with increased cardiovascular risk (CVR), its relationship with heart failure (HF) and left ventricular (LV) dysfunction is not fully understood. AIMS: We sought to determine whether MS is associated to LV systolic and diastolic dysfunction in a sample of patients with MS and no symptoms for HF. SUBJECTS AND METHODS: We enrolled 6422 consecutive asymptomatic patients admitted to echo-lab for a routine echocardiogram. We calculated LV systolic and diastolic function, by Simpson biplane method and validated Doppler parameters, respectively. MS was diagnosed if three or more CVR factors were found. RESULTS: LV systolic function was evaluated in 6175 patients (96.2%). In the group of patients without MS (n = 5630), the prevalence of systolic dysfunction was 10.8% (n = 607) while in the group of patients with MS (n = 545) it was 12.5% (n = 87), (RR1.57; CI 95% 1.2-2.0; P < 0.001). Diastolic function was evaluated in 3936 patients (61.3%). In the group of patients without MS (n = 3566) the prevalence of diastolic dysfunction was 33.3% (n = 1187), while in patients with MS (n = 370) it was 45.7% (n = 169), (RR1.68; CI95% 1.3-2.0; P < 0.001). After adjustment for age and gender, MS proved to be an independent predictor of LV systolic and diastolic dysfunction. CONCLUSIONS: Our data show that asymptomatic LV systolic and diastolic dysfunction, is correlated with MS and demonstrate that echocardiography is a useful tool to detect patients at high risk for HF. Echocardiography in asymptomatic patients with MS may lead to a therapy initiation at early stages to prevent future cardiovascular events and HF. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC5353398/ /pubmed/28465894 http://dx.doi.org/10.4103/2211-4122.127410 Text en Copyright: © 2013 Journal of Cardiovascular Echography http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
La Carrubba, Salvatore
Todaro, Maria Chiara
Zito, Concetta
Antonini-Canterin, Francesco
Monte, Ines Paola
Caso, Pio
Colonna, Paolo
de Gregorio, Cesare
Pezzano, Antonio
Benedetto, Frank
Salvo, Giovanni Di
Carerj, Scipione
Bello, Vitantonio Di
Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title_full Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title_fullStr Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title_full_unstemmed Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title_short Asymptomatic Left Ventricular Dysfunction and Metabolic Syndrome: Results from an Italian Multicenter Study
title_sort asymptomatic left ventricular dysfunction and metabolic syndrome: results from an italian multicenter study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353398/
https://www.ncbi.nlm.nih.gov/pubmed/28465894
http://dx.doi.org/10.4103/2211-4122.127410
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