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Non-medical use of olanzapine by people on methadone treatment

Aims and method We examined non-medical use (NMU) of olanzapine among adults on methadone treatment. Information was collected on patient demographics and NMU of olanzapine. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was administered to assess risk among current users of...

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Autores principales: James, Philip David, Fida, Ali Shaik, Konovalov, Pavel, Smyth, Bobby P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal College of Psychiatrists 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353524/
https://www.ncbi.nlm.nih.gov/pubmed/28377810
http://dx.doi.org/10.1192/pb.bp.115.052886
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author James, Philip David
Fida, Ali Shaik
Konovalov, Pavel
Smyth, Bobby P.
author_facet James, Philip David
Fida, Ali Shaik
Konovalov, Pavel
Smyth, Bobby P.
author_sort James, Philip David
collection PubMed
description Aims and method We examined non-medical use (NMU) of olanzapine among adults on methadone treatment. Information was collected on patient demographics and NMU of olanzapine. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was administered to assess risk among current users of olanzapine. Results Ninety-two clients participated and 30% reported lifetime history of NMU of olanzapine. Nine people reported doses of 30 mg or higher on a typical day of use, with three typically using 100 mg. The most common reasons for use were to relieve anxiety and to aid sleep, but a quarter used it to ‘get stoned’. Eleven participants (12%) reported NMU of olanzapine in the preceding month. Eight completed the ASSIST with four scoring in the high-risk zone. Clinical implications Self-medication is the dominant motivator for NMU of olanzapine, but hedonic motivations also occur. A small minority show features of dependency. All doctors should be aware of the potential NMU of olanzapine, especially among patients with history of addiction.
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spelling pubmed-53535242017-04-04 Non-medical use of olanzapine by people on methadone treatment James, Philip David Fida, Ali Shaik Konovalov, Pavel Smyth, Bobby P. BJPsych Bull Original Papers Aims and method We examined non-medical use (NMU) of olanzapine among adults on methadone treatment. Information was collected on patient demographics and NMU of olanzapine. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) was administered to assess risk among current users of olanzapine. Results Ninety-two clients participated and 30% reported lifetime history of NMU of olanzapine. Nine people reported doses of 30 mg or higher on a typical day of use, with three typically using 100 mg. The most common reasons for use were to relieve anxiety and to aid sleep, but a quarter used it to ‘get stoned’. Eleven participants (12%) reported NMU of olanzapine in the preceding month. Eight completed the ASSIST with four scoring in the high-risk zone. Clinical implications Self-medication is the dominant motivator for NMU of olanzapine, but hedonic motivations also occur. A small minority show features of dependency. All doctors should be aware of the potential NMU of olanzapine, especially among patients with history of addiction. Royal College of Psychiatrists 2016-12 /pmc/articles/PMC5353524/ /pubmed/28377810 http://dx.doi.org/10.1192/pb.bp.115.052886 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0 This is an open-access article published by the Royal College of Psychiatrists and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Papers
James, Philip David
Fida, Ali Shaik
Konovalov, Pavel
Smyth, Bobby P.
Non-medical use of olanzapine by people on methadone treatment
title Non-medical use of olanzapine by people on methadone treatment
title_full Non-medical use of olanzapine by people on methadone treatment
title_fullStr Non-medical use of olanzapine by people on methadone treatment
title_full_unstemmed Non-medical use of olanzapine by people on methadone treatment
title_short Non-medical use of olanzapine by people on methadone treatment
title_sort non-medical use of olanzapine by people on methadone treatment
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353524/
https://www.ncbi.nlm.nih.gov/pubmed/28377810
http://dx.doi.org/10.1192/pb.bp.115.052886
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