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CD8(+) T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage

CD8(+) T cells directed against beta cell autoantigens are considered relevant for the pathogenesis of type 1 diabetes. Using single cell T cell receptor sequencing of CD8(+) T cells specific for the IGRP(265-273) epitope, we examined whether there was expansion of clonotypes and sharing of T cell r...

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Detalles Bibliográficos
Autores principales:	Fuchs, Yannick F., Eugster, Anne, Dietz, Sevina, Sebelefsky, Christian, Kühn, Denise, Wilhelm, Carmen, Lindner, Annett, Gavrisan, Anita, Knoop, Jan, Dahl, Andreas, Ziegler, Anette-G., Bonifacio, Ezio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353542/ https://www.ncbi.nlm.nih.gov/pubmed/28300170 http://dx.doi.org/10.1038/srep44661

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