Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

Osteoclasts degrade bone matrix proteins via the secretion of lysosomal enzymes. However, the precise mechanisms by which lysosomal components are transported and fused to the bone-apposed plasma membrane, termed ruffled border membrane, remain elusive. Here, we identified coronin 1A as a negative r...

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Detalles Bibliográficos
Autores principales: Ohmae, Saori, Noma, Naruto, Toyomoto, Masayasu, Shinohara, Masahiro, Takeiri, Masatoshi, Fuji, Hiroaki, Takemoto, Kenji, Iwaisako, Keiko, Fujita, Tomoko, Takeda, Norihiko, Kawatani, Makoto, Aoyama, Mineyoshi, Hagiwara, Masatoshi, Ishihama, Yasushi, Asagiri, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353622/
https://www.ncbi.nlm.nih.gov/pubmed/28300073
http://dx.doi.org/10.1038/srep41710

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