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Rational Design of Protein C Activators

In addition to its procoagulant and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protease thrombin activates the anticoagulant protein C in a reaction that requires the cofactor thrombomodulin and the endothelial protein C receptor. Once in the circulation,...

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Detalles Bibliográficos
Autores principales:	Barranco-Medina, Sergio, Murphy, Mary, Pelc, Leslie, Chen, Zhiwei, Di Cera, Enrico, Pozzi, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5353707/ https://www.ncbi.nlm.nih.gov/pubmed/28294177 http://dx.doi.org/10.1038/srep44596

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